PDF(Pubmed)
Abstract：
BACKGROUND: The bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore, these implants may be a good option for enhancing and stabilizing maxillary sinuses. The purpose of this study was to compare two xenografts, Bone+B® and InterOss®, for the reconstruction of rabbit calvaria defects.
METHODS: The study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8-millimeter defects. A control group was used, as well as two treatment groups utilizing Bone+B® Grafts and InterOss® Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.
RESULTS: With the application of Bone+B® graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (±5.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (±3.65). Using InterOss® grafts, bone formation was 61% to 75%, the mean was 65.83% (±4.75), and the remaining material was 9% to 18%, with a mean of 13.17% (±3.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (±6.11). InterOss® had lower inflammation levels than other groups, but the difference was not statistically significant (p > .05).
CONCLUSIONS: InterOss® bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone+B® improves healing and bone quality, thus making it an alternative to InterOss®.
METHODS: The study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8-millimeter defects. A control group was used, as well as two treatment groups utilizing Bone+B® Grafts and InterOss® Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.
RESULTS: With the application of Bone+B® graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (±5.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (±3.65). Using InterOss® grafts, bone formation was 61% to 75%, the mean was 65.83% (±4.75), and the remaining material was 9% to 18%, with a mean of 13.17% (±3.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (±6.11). InterOss® had lower inflammation levels than other groups, but the difference was not statistically significant (p > .05).
CONCLUSIONS: InterOss® bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone+B® improves healing and bone quality, thus making it an alternative to InterOss®.
摘要：
背景：骨再生疗法通常用于植入物骨支撑不足的患者，特别是拔牙后。源自动物组织的异种移植物是有效的骨重建选择,其抵抗再吸收并造成传播疾病的低风险。因此,这些植入物可能是增强和稳定上颌窦的良好选择。这项研究的目的是比较两种异种移植物，Bone+B®和InterOss®，用于重建兔颅骨缺损。
方法：本研究涉及7只雄性新西兰白兔。在外科手术中,通过产生三个8毫米缺陷，在中线颅骨的两侧产生了21个斑点。使用对照组，以及使用骨+B®移植物和InterOss®移植物的两个治疗组。三个月后,兔子被安乐死，然后进行病理评估。这些样本的分析集中在骨形成上，异种移植剩余材料，和炎症水平，使用AdobePhotoshopCS8.0和SPSS版本24。
结果：随着Bone+B®移植物的应用，骨形成从32%到45%,平均值为37.80%(±5.63)，其余材料从28%到37%不等，平均值为32.60%(±3.65)。使用InterOss®移植物，骨形成为61%至75%，平均值为65.83%(±4.75)，剩余材料为9%到18%，平均值为13.17%(±3.06)。对照组的骨形成为10％至25％，平均值为17.17%(±6.11)。InterOss®的炎症水平低于其他组，但差异无统计学意义(p>.05)。
结论：InterOss®骨粉是颌面外科和骨重建的最佳选择。这是由于更多的骨骼形成，剩余材料较少，和较低的炎症水平。与对照组相比,骨+B®改善愈合和骨骼质量，从而使其成为InterOss®的替代品。
方法：本研究涉及7只雄性新西兰白兔。在外科手术中,通过产生三个8毫米缺陷，在中线颅骨的两侧产生了21个斑点。使用对照组，以及使用骨+B®移植物和InterOss®移植物的两个治疗组。三个月后,兔子被安乐死，然后进行病理评估。这些样本的分析集中在骨形成上，异种移植剩余材料，和炎症水平，使用AdobePhotoshopCS8.0和SPSS版本24。
结果：随着Bone+B®移植物的应用，骨形成从32%到45%,平均值为37.80%(±5.63)，其余材料从28%到37%不等，平均值为32.60%(±3.65)。使用InterOss®移植物，骨形成为61%至75%，平均值为65.83%(±4.75)，剩余材料为9%到18%，平均值为13.17%(±3.06)。对照组的骨形成为10％至25％，平均值为17.17%(±6.11)。InterOss®的炎症水平低于其他组，但差异无统计学意义(p>.05)。
结论：InterOss®骨粉是颌面外科和骨重建的最佳选择。这是由于更多的骨骼形成，剩余材料较少，和较低的炎症水平。与对照组相比,骨+B®改善愈合和骨骼质量，从而使其成为InterOss®的替代品。
