穿心莲内酯抑制 NF - kB 和 COX - 2 通过促进 PTEN 表达和抑制 PI3K / AKT 信号通路调节宫颈癌进展.
关键词: Andrographolide COX-2 Cervical cancer NF-kB PI3K PTEN
Mesh : Uterine Cervical Neoplasms / drug therapy metabolism pathology genetics Humans PTEN Phosphohydrolase / metabolism genetics Female Diterpenes / pharmacology NF-kappa B / metabolism Signal Transduction / drug effects Proto-Oncogene Proteins c-akt / metabolism Animals Phosphatidylinositol 3-Kinases / metabolism Mice Cyclooxygenase 2 / metabolism Cell Line, Tumor Cell Proliferation / drug effects Apoptosis / drug effects Molecular Docking Simulation Xenograft Model Antitumor Assays Disease Progression Gene Expression Regulation, Neoplastic / drug effects Cell Movement / drug effects
来 源:
DOI:10.1038/s41598-024-57304-7
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