Abstract：
UNASSIGNED: Data supporting treatment recommendations for congenital nasolacrimal duct obstruction (CNLDO) in patients with craniofacial abnormalities is scarce. This study reports the incidence, clinical features, and outcomes of patients with concomitant craniofacial abnormalities and CNLDO.
UNASSIGNED: This multi-center, retrospective, population-based cohort study included all patients diagnosed with CNLDO before age 6 during a 10-year period in a single US county.
UNASSIGNED: Of the 17,713 live births during the study period, 1998 infants were diagnosed with CNLDO, among whom 41 (2.05%) had associated congenital craniofacial abnormalities, yielding a birth prevalence of 23.1 (95% CI 16.6-31.4) per 10,000 live births. Craniofacial patients were significantly older at time of diagnosis (6.2 months) compared to uncomplicated CNLDO (3.7 months; p = 0.035). There was no significant difference in mean age at spontaneous CNLDO resolution, but 31.7% of craniofacial patients required probing for CNLDO resolution, compared to 14.5% in the CNLDO group (OR 2.76 [95%CI 1.41-5.39] p = 0.003). All but two patients with craniofacial abnormalities had resolution of symptoms after initial probing. Intraoperative probing findings indicated that 8 of 13 craniofacial patients had complex obstructions.
UNASSIGNED: The similar age at spontaneous resolution indicates that watchful waiting until approximately one year of age is a reasonable approach even in patients with craniofacial abnormalities, though more of these patients may require surgical intervention.
UNASSIGNED: This multi-center, retrospective, population-based cohort study included all patients diagnosed with CNLDO before age 6 during a 10-year period in a single US county.
UNASSIGNED: Of the 17,713 live births during the study period, 1998 infants were diagnosed with CNLDO, among whom 41 (2.05%) had associated congenital craniofacial abnormalities, yielding a birth prevalence of 23.1 (95% CI 16.6-31.4) per 10,000 live births. Craniofacial patients were significantly older at time of diagnosis (6.2 months) compared to uncomplicated CNLDO (3.7 months; p = 0.035). There was no significant difference in mean age at spontaneous CNLDO resolution, but 31.7% of craniofacial patients required probing for CNLDO resolution, compared to 14.5% in the CNLDO group (OR 2.76 [95%CI 1.41-5.39] p = 0.003). All but two patients with craniofacial abnormalities had resolution of symptoms after initial probing. Intraoperative probing findings indicated that 8 of 13 craniofacial patients had complex obstructions.
UNASSIGNED: The similar age at spontaneous resolution indicates that watchful waiting until approximately one year of age is a reasonable approach even in patients with craniofacial abnormalities, though more of these patients may require surgical intervention.
摘要：
■支持颅面畸形患者先天性鼻泪管阻塞（CNLDO）治疗建议的数据很少。这项研究报告了发病率，临床特征,以及伴有颅面部异常和CNLDO的患者的结局。
■这个多中心，回顾性,基于人群的队列研究纳入了美国一个县10年内所有6岁之前诊断为CNLDO的患者.
■在研究期间的17713例活产中，1998年婴儿被诊断出患有CNLDO，其中41人(2.05%)患有先天性颅面畸形，每10,000例活产婴儿的出生患病率为23.1（95％CI16.6-31.4）。与无并发症的CNLDO（3.7个月；p=0.035）相比，颅面患者在诊断时（6.2个月）明显更老。自发CNLDO分辨率的平均年龄没有显着差异，但是31.7%的颅面患者需要探测CNLDO分辨率，与CNLDO组的14.5%相比(OR2.76[95CI1.41-5.39]p=0.003)。除两名颅面异常患者外，所有患者在初次探查后症状均得到缓解。术中探查结果表明，13例颅面部患者中有8例存在复杂的阻塞。
■自发解决的相似年龄表明，即使在颅面畸形患者中，观察等待大约一岁也是一种合理的方法，尽管这些患者中可能有更多需要手术干预。
■这个多中心，回顾性,基于人群的队列研究纳入了美国一个县10年内所有6岁之前诊断为CNLDO的患者.
■在研究期间的17713例活产中，1998年婴儿被诊断出患有CNLDO，其中41人(2.05%)患有先天性颅面畸形，每10,000例活产婴儿的出生患病率为23.1（95％CI16.6-31.4）。与无并发症的CNLDO（3.7个月；p=0.035）相比，颅面患者在诊断时（6.2个月）明显更老。自发CNLDO分辨率的平均年龄没有显着差异，但是31.7%的颅面患者需要探测CNLDO分辨率，与CNLDO组的14.5%相比(OR2.76[95CI1.41-5.39]p=0.003)。除两名颅面异常患者外，所有患者在初次探查后症状均得到缓解。术中探查结果表明，13例颅面部患者中有8例存在复杂的阻塞。
■自发解决的相似年龄表明，即使在颅面畸形患者中，观察等待大约一岁也是一种合理的方法，尽管这些患者中可能有更多需要手术干预。
