PDF(Pubmed)
Abstract：
Melanoma, accounting for a significant proportion of skin cancer-related deaths, has variable survival outcomes based on the stage at diagnosis and treatment efficacy. Traditional treatments, while effective, pose risks of scarring and systemic side effects. Laser therapy offers an emerging non-surgical alternative, with CO2 lasers particularly showing promise in palliative care.A comprehensive search was conducted using PubMed, focusing on laser therapy for melanoma treatment. The search included studies on both stand-alone and adjunct laser therapies, with inclusion criteria requiring peer-reviewed articles detailing treatment outcomes for primary, recurrent, or metastatic melanoma.The literature shows that laser therapy for melanoma falls into four major types when categorized by laser medium: solid-state, diode, pulse-dye, and gas (CO2). Data on solid-state lasers for melanoma are limited and their use remains controversial. However, one study with high-energy pulsed neodymium lasers reported a 5-year survival of 82.9% with minimal adverse effects for primary melanoma. CO2 laser therapy has been effective for palliative treatment, with one study showing 54.8% of patients with recurrent melanoma surviving 5.4 years post-ablation. For metastatic melanoma, numerous studies have shown that CO2 laser therapy can provide symptomatic relief and disease control. Combination therapies using lasers and immune-based therapies have demonstrated enhanced outcomes and immune activation, highlighting the potential of laser therapies in melanoma management.While traditional treatments remain the standard for primary melanoma, laser therapies, particularly CO2 laser ablation, show substantial promise in palliative care for metastatic melanoma. Careful patient selection and assessment are crucial for achieving positive outcomes.
摘要：
黑色素瘤,占皮肤癌相关死亡的很大比例，根据诊断和治疗效果的阶段，生存结果存在差异。传统治疗,虽然有效，造成疤痕和全身副作用的风险。激光治疗提供了一种新兴的非手术替代方案，二氧化碳激光在姑息治疗中特别有希望。使用PubMed进行了全面搜索，专注于激光治疗黑色素瘤。搜索包括独立和辅助激光治疗的研究，纳入标准要求同行评审的文章详细说明初级治疗结果，经常性,或者转移性黑色素瘤.文献显示，当按激光介质分类时，黑色素瘤的激光治疗分为四种主要类型：固态，二极管,脉冲染料，气体（CO2）。用于黑色素瘤的固态激光器的数据有限，其使用仍存在争议。然而,一项使用高能脉冲钕激光的研究报告,原发性黑色素瘤的5年生存率为82.9%,不良反应最小.CO2激光治疗对姑息治疗有效，一项研究显示，54.8%的复发性黑色素瘤患者在消融后存活5.4年。对于转移性黑色素瘤，许多研究表明，CO2激光治疗可以提供症状缓解和疾病控制。使用激光和基于免疫的疗法的联合疗法已显示出增强的结果和免疫激活，强调激光治疗在黑色素瘤治疗中的潜力。虽然传统治疗仍然是原发性黑色素瘤的标准，激光治疗,特别是CO2激光烧蚀，在转移性黑色素瘤的姑息治疗中显示出实质性的希望。仔细的患者选择和评估对于取得积极成果至关重要。
