Abstract：
Lymphoblastic lymphoma (LBL) with an early T-cell precursor phenotype has only been rarely reported. Nijmegen breakage syndrome (NBS) is an inherited chromosomal instability disorder with known predisposition to malignancies that is very rare as well. We report a case of early T-precursor LBL (ETP-LBL) in a patient with NBS, a rare combination that has not been reported. We raise the question of whether a chromosomal instability disorder such as NBS increases the propensity for early T-precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL), given that ETP-ALL has been shown to have increased genomic instability compared to T-ALL.
摘要：
具有早期T细胞前体表型的淋巴母细胞淋巴瘤（LBL）很少有报道。Nijmegen断裂综合征（NBS）是一种遗传性染色体不稳定疾病，已知易患恶性肿瘤，这种疾病也非常罕见。我们报告了一例NBS患者的早期T前体LBL（ETP-LBL），一种罕见的组合，尚未报道。我们提出了一个问题，即NBS等染色体不稳定疾病是否会增加早期T前体急性淋巴细胞白血病/淋巴瘤（ETP-ALL/LBL）的倾向，鉴于与T-ALL相比，ETP-ALL已被证明具有增加的基因组不稳定性。
