PDF(Pubmed)
Abstract：
Encapsulation and drying technologies allow the engineering of innovative raw materials from plant biodiversity, with potential applications in pharmaceutical and cosmetic fields. Lipid-based nanoencapsulation stands out for its efficiency, ease of production, and versatility in encapsulating substances, whether hydrophilic or lipophilic. This work aimed at encapsulating pequi oil in liposomes and freeze-dried liposomes to enhance its stability and functional benefits, such as skin hydration and anti-aging effects, for use in innovative cosmetic formulations. Pequi oil-extracted from the Caryocar brasiliense fruit pulp, a plant species from Brazilian plant biodiversity-is rich in secondary metabolites and fatty acids. Liposomes and dried liposomes offer controlled production processes and seamless integration into cosmetic formulations. The physicochemical analysis of the developed liposomes confirmed that the formulations are homogeneous and electrokinetically stable, as evidenced by consistent particle size distribution and zeta potential values, respectively. The gel-type formulations loaded with the dried liposomes exhibit enhanced skin hydration, improved barrier function, and refined microrelief, indicating improvements in skin conditions. These results highlight the potential of dried liposomes containing pequi oil for the development of innovative cosmeceutical products. This research contributes to the valorization of Brazilian biodiversity by presenting an innovative approach to leveraging the dermatological benefits of pequi oil in cosmetic applications.
摘要：
封装和干燥技术允许从植物生物多样性的创新原材料的工程，在制药和化妆品领域具有潜在的应用。基于脂质的纳米封装因其效率而脱颖而出，易于生产，和封装物质的多功能性，无论是亲水性的还是亲脂性的。这项工作的目的是在脂质体和冻干脂质体中封装皮油，以增强其稳定性和功能益处，如皮肤水合作用和抗衰老作用，用于创新的化妆品配方。从巴西Caryocar果肉中提取的Pequi油，来自巴西植物生物多样性的一种植物，富含次生代谢产物和脂肪酸。脂质体和干燥脂质体提供受控的生产过程和无缝整合到化妆品制剂中。开发的脂质体的物理化学分析证实，该制剂是均匀的和电动稳定的，如一致的粒度分布和zeta电位值所证明的，分别。负载有干燥脂质体的凝胶型制剂表现出增强的皮肤水合作用，改进的屏障功能，和精致的微浮雕，表明皮肤状况的改善。这些结果突出了含有pequi油的干燥脂质体在开发创新药妆产品方面的潜力。这项研究通过提出一种创新的方法来利用Pequi油在化妆品应用中的皮肤病学益处，从而为巴西生物多样性的价值做出了贡献。
