PDF(Pubmed)
Abstract：
The involvement of the gut microbiota in anti-cancer treatment has gained increasing attention. Alterations to the structure and function of the gut bacteria are important factors in the development of cancer as well as the efficacy of chemotherapy. Recent studies have confirmed that the gut microbiota and related metabolites influence the pharmacological activity of chemotherapeutic agents through interactions with the immune system. This review aims to summarize the current knowledge of how malignant tumor and chemotherapy affect the gut microbiota, how the gut microbiota regulates host immune response, and how interactions between the gut microbiota and host immune response influence the efficacy of chemotherapy. Recent advances in strategies for increasing the efficiency of chemotherapy based on the gut microbiota are also described. Deciphering the complex homeostasis maintained by the gut microbiota and host immunity provides a solid scientific basis for bacterial intervention in chemotherapy.
摘要：
肠道菌群在抗癌治疗中的参与越来越受到关注。肠道细菌结构和功能的改变是癌症发展以及化疗疗效的重要因素。最近的研究已经证实，肠道菌群和相关代谢产物通过与免疫系统的相互作用影响化疗药物的药理活性。这篇综述旨在总结目前有关恶性肿瘤和化疗如何影响肠道菌群的知识。肠道微生物群如何调节宿主免疫反应，以及肠道菌群和宿主免疫反应之间的相互作用如何影响化疗的疗效。还描述了基于肠道微生物群提高化疗效率的策略的最新进展。破译由肠道微生物群和宿主免疫维持的复杂稳态为化疗中的细菌干预提供了坚实的科学依据。
