PDF(Pubmed)
Abstract：
Despite significant strides in vaccine research and the availability of vaccines for many infectious diseases, the threat posed by both known and emerging infectious diseases persists. Moreover, breakthrough infections following vaccination remain a concern. Therefore, the development of novel vaccines is imperative. These vaccines must exhibit robust protective efficacy, broad-spectrum coverage, and long-lasting immunity. One promising avenue in vaccine development lies in leveraging T-cells, which play a crucial role in adaptive immunity and regulate immune responses during viral infections. T-cell recognition can target highly variable or conserved viral proteins, and memory T-cells offer the potential for durable immunity. Consequently, T-cell-based vaccines hold promise for advancing vaccine development efforts. This review delves into the latest research advancements in T-cell-based vaccines across various platforms and discusses the associated challenges.
摘要：
尽管在疫苗研究和许多传染病的疫苗供应方面取得了重大进展，已知和新出现的传染病构成的威胁仍然存在。此外，疫苗接种后的突破性感染仍然令人担忧。因此,新型疫苗的开发势在必行。这些疫苗必须表现出强大的保护功效，广谱覆盖,和持久的免疫力。疫苗开发的一个有希望的途径是利用T细胞，在适应性免疫中起着至关重要的作用，并在病毒感染期间调节免疫反应。T细胞识别可以靶向高度可变或保守的病毒蛋白，和记忆T细胞提供持久免疫的潜力。因此,基于T细胞的疫苗有望推进疫苗开发工作。这篇综述深入研究了各种平台上基于T细胞的疫苗的最新研究进展，并讨论了相关的挑战。
