PDF(Pubmed)
Abstract：
During the COVID-19 pandemic, several vaccines were developed to limit the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, due to SARS-CoV-2 mutations and uneven vaccination coverage among populations, a series of COVID-19 waves have been caused by different variants of concern (VOCs). Despite the updated vaccine formulations for the new VOC, the benefits of additional COVID-19 vaccine doses have raised many doubts, even among high-risk groups such as healthcare workers (HCWs). We examined the factors underlying hesitancy to receive COVID-19 booster vaccine doses and analysed the anti-SARS-CoV-2 IgG antibody response after booster vaccination among HCWs. Our study found that 42% of the HCWs were hesitant about the second booster dose, while 7% reported no intent to get vaccinated with any additional doses. As reasons for not vaccinating, participants most frequently highlighted lack of time, negative experiences with previous vaccinations, and immunity conferred by past infections. In addition, we found the lowest post-vaccination antibody titres among HCWs who did not receive any vaccine booster dose and the highest among HCWs vaccinated with two booster doses.
摘要：
在COVID-19大流行期间，我们开发了几种疫苗来限制严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)的传播.然而,由于SARS-CoV-2突变和人群疫苗接种覆盖率不均，一系列COVID-19波是由不同的关注变种(VOCs)引起的。尽管更新了新VOC的疫苗配方，额外的COVID-19疫苗剂量的好处引起了许多怀疑，甚至在高危人群中，如医护人员(HCWs)。我们检查了不愿接受COVID-19加强疫苗剂量的潜在因素，并分析了HCWs加强疫苗接种后的抗SARS-CoV-2IgG抗体反应。我们的研究发现，42%的HCWs对第二次加强剂量犹豫不决，而7%的人报告没有打算接种任何额外剂量的疫苗。作为不接种疫苗的原因，参与者最常强调缺乏时间，以前接种疫苗的负面经验，和过去感染赋予的免疫力。此外,我们发现,在未接受任何疫苗加强剂量的HCWs中,疫苗接种后抗体滴度最低,在接受两次加强剂量疫苗接种的HCWs中,抗体滴度最高.
