关键词: CNS COVID-19 SARS-CoV-2 neurology viral infection

Mesh : Animals Humans Central Nervous System / virology immunology COVID-19 / immunology virology Cytokine Release Syndrome / immunology Inflammation / immunology virology SARS-CoV-2 / immunology pathogenicity

来  源:   DOI:10.3390/v16050663   PDF(Pubmed)

Abstract:
Initially reported as pneumonia of unknown origin, COVID-19 is increasingly being recognized for its impact on the nervous system, despite nervous system invasions being extremely rare. As a result, numerous studies have been conducted to elucidate the mechanisms of nervous system damage and propose appropriate coping strategies. This review summarizes the mechanisms by which SARS-CoV-2 invades and damages the central nervous system, with a specific focus on aspects apart from the immune response and inflammatory storm. The latest research findings on these mechanisms are presented, providing new insights for further in-depth research.
摘要:
最初报告为不明原因肺炎,COVID-19对神经系统的影响越来越受到认可,尽管神经系统入侵极为罕见。因此,已经进行了许多研究来阐明神经系统损害的机制并提出适当的应对策略。本文综述了SARS-CoV-2侵入和损害中枢神经系统的机制。特别关注免疫反应和炎症风暴之外的方面。介绍了有关这些机制的最新研究成果,为进一步深入研究提供新的见解。
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