PDF(Pubmed)
Abstract：
Titanium implants undergo an aging process through surface hydrocarbon deposition, resulting in decreased wettability and bioactivity. Plasma treatment was shown to significantly reduce surface hydrocarbons, thus improving implant hydrophilicity and enhancing the osseointegration process. This study investigates the effect of plasma surface treatment on bone-to-implant contact (BIC) of implants presenting a nanostructured calcium-incorporated surface (XPEED®). Following a Randomized Controlled Trial (RCT) design, patients undergoing implant surgery in the posterior maxilla received additional plasma-treated (n = 7) or -untreated (n = 5) 3.5 × 8 mm implants that were retrieved after a 4-week healing period for histological examination. Histomorphometric analysis showed that plasma-treated implants exhibited a 38.7% BIC rate compared to 22.4% of untreated implants (p = 0.002), indicating enhanced osseointegration potential. Histological images also revealed increased bone formation and active osteoblastic activity around plasma-treated implants when compared to untreated specimens. The findings suggest that plasma treatment improves surface hydrophilicity and biological response, facilitating early bone formation around titanium implants. This study underscores the importance of surface modifications in optimizing implant integration and supports the use of plasma treatment to enhance osseointegration, thereby improving clinical outcomes in implant dentistry and offering benefits for immediate and early loading protocols, particularly in soft bone conditions.
摘要：
钛植入物通过表面碳氢化合物沉积经历老化过程，导致润湿性和生物活性降低。等离子体处理显着减少表面碳氢化合物，从而提高种植体的亲水性和增强骨整合过程。这项研究调查了等离子体表面处理对呈现纳米结构钙掺入表面（XPEED®）的植入物的骨与植入物接触（BIC）的影响。在随机对照试验（RCT）设计之后，在上颌骨后部接受植入物手术的患者接受了额外的等离子治疗(n=7)或未治疗(n=5)3.5×8mm植入物,这些植入物在4周的愈合期后进行组织学检查.组织形态分析显示，经等离子体处理的植入物表现出38.7%的BIC率，而未经处理的植入物为22.4%(p=0.002)。表明骨整合潜力增强。组织学图像还显示，与未处理的标本相比，等离子体处理的植入物周围的骨形成和成骨细胞活性增加。结果表明，等离子体处理提高了表面亲水性和生物响应，促进钛植入物周围的早期骨形成。这项研究强调了表面修饰在优化植入物整合中的重要性，并支持使用等离子体治疗来增强骨整合。从而改善植入物牙科的临床结果，并为即时和早期加载方案提供益处，特别是在软骨条件下。
