PDF(Pubmed)
Abstract：
BACKGROUND: Reducing a child\'s level of anxiety before magnetic resonance imaging (MRI) procedures allows for better behavioral outcomes. The aim of this retrospective study was to evaluate anxiolytic efficacy of Midazolam/γ-cyclodextrin oral formulation.
METHODS: We retrospectively reviewed 100 medical charts of children who, between 1 February and 31 July 2022, underwent MRI under general anesthesia with or without premedication with midazolam/γ-cyclodextrin. Primary outcome was comparison of behavior to facemask positioning, while secondary endpoints were degree of drugs acceptance, anxiolytic effect evaluation, child\'s behavior on separation, and sevoflurane need.
RESULTS: Facemask positioning was accepted by 58% of the midazolam/γ-cyclodextrin group compared to 22% of children in the control group. The rate of acceptance was >90%. At the moment of separation from parent, none of the premedicated children needed to be restrained compared to 18% in the control group. A lower percentage of sevoflurane was needed for eye-closure at induction of anesthesia and for anesthesia maintenance. At emergence from anesthesia, 46% of children in the premedicated group compared to 66% of children in the control group showed transient agitation.
CONCLUSIONS: Midazolam/γ-cyclodextrin showed a good profile of acceptance, satisfactory anxiolytic properties, and reduced need for anesthetics when administered to children before MRI under general anesthesia.
METHODS: We retrospectively reviewed 100 medical charts of children who, between 1 February and 31 July 2022, underwent MRI under general anesthesia with or without premedication with midazolam/γ-cyclodextrin. Primary outcome was comparison of behavior to facemask positioning, while secondary endpoints were degree of drugs acceptance, anxiolytic effect evaluation, child\'s behavior on separation, and sevoflurane need.
RESULTS: Facemask positioning was accepted by 58% of the midazolam/γ-cyclodextrin group compared to 22% of children in the control group. The rate of acceptance was >90%. At the moment of separation from parent, none of the premedicated children needed to be restrained compared to 18% in the control group. A lower percentage of sevoflurane was needed for eye-closure at induction of anesthesia and for anesthesia maintenance. At emergence from anesthesia, 46% of children in the premedicated group compared to 66% of children in the control group showed transient agitation.
CONCLUSIONS: Midazolam/γ-cyclodextrin showed a good profile of acceptance, satisfactory anxiolytic properties, and reduced need for anesthetics when administered to children before MRI under general anesthesia.
摘要：
背景：在磁共振成像（MRI）程序之前降低儿童的焦虑水平可以获得更好的行为结果。这项回顾性研究的目的是评估咪达唑仑/γ-环糊精口服制剂的抗焦虑疗效。
方法：我们回顾性回顾了100例儿童的医疗图表，在2022年2月1日至7月31日期间,患者在全身麻醉下接受了MRI检查,无论是否使用咪达唑仑/γ-环糊精术前用药.主要结果是行为与面罩定位的比较，而次要终点是药物接受程度，抗焦虑效果评价，孩子在分离时的行为，和七氟醚需要。
结果：咪达唑仑/γ-环糊精组58％的儿童接受了面罩定位，而对照组为22％。接受率>90%。在与父母分离的那一刻，与对照组的18％相比，未接受药物治疗的儿童不需要约束。麻醉诱导时闭眼和麻醉维持时需要较低百分比的七氟醚。麻醉出现时，药物治疗组46％的儿童与对照组66％的儿童表现出短暂的躁动。
结论：咪达唑仑/γ-环糊精表现出良好的接受度，令人满意的抗焦虑性能，在全身麻醉下在MRI之前对儿童进行麻醉时，减少了对麻醉药的需求。
方法：我们回顾性回顾了100例儿童的医疗图表，在2022年2月1日至7月31日期间,患者在全身麻醉下接受了MRI检查,无论是否使用咪达唑仑/γ-环糊精术前用药.主要结果是行为与面罩定位的比较，而次要终点是药物接受程度，抗焦虑效果评价，孩子在分离时的行为，和七氟醚需要。
结果：咪达唑仑/γ-环糊精组58％的儿童接受了面罩定位，而对照组为22％。接受率>90%。在与父母分离的那一刻，与对照组的18％相比，未接受药物治疗的儿童不需要约束。麻醉诱导时闭眼和麻醉维持时需要较低百分比的七氟醚。麻醉出现时，药物治疗组46％的儿童与对照组66％的儿童表现出短暂的躁动。
结论：咪达唑仑/γ-环糊精表现出良好的接受度，令人满意的抗焦虑性能，在全身麻醉下在MRI之前对儿童进行麻醉时，减少了对麻醉药的需求。
