PDF(Pubmed)
Abstract：
Lung cancer has the highest incidence and cancer-related mortality worldwide. In Portugal, it ranks as the fourth most common cancer, with nearly 6000 new cases being diagnosed every year. Lung cancer is the main cause of cancer-related death among males and the third cause of cancer-related death in females. Despite the globally accepted guidelines and recommendations for what would be the ideal path for a lung cancer patient, several challenges occur in real clinical management across the world. The recommendations emphasize the importance of adequate screening of high-risk individuals, a precise tumour biopsy, and an accurate final diagnosis to confirm the neoplastic nature of the nodule. A detailed histological classification of the lung tumour type and a comprehensive molecular characterization are of utmost importance for the selection of an efficacious and patient-directed therapeutic approach. However, in the context of the Portuguese clinical organization and the national healthcare system, there are still several gaps in the ideal pathway for a lung cancer patient, involving aspects ranging from the absence of a national lung cancer screening programme through difficulties in histological diagnosis and molecular characterization to challenges in therapeutic approaches. In this manuscript, we address the most relevant weaknesses, presenting several proposals for potential solutions to improve the management of lung cancer patients, helping to decisively improve their overall survival and quality of life.
摘要：
肺癌是全球发病率和癌症相关死亡率最高的癌症。在葡萄牙,它是第四常见的癌症，每年诊断出近6000例新病例。肺癌是男性癌症相关死亡的主要原因，是女性癌症相关死亡的第三大原因。尽管全球公认的指南和建议是肺癌患者的理想路径，在世界各地的实际临床管理中出现了一些挑战.建议强调对高危人士进行充分筛查的重要性,精确的肿瘤活检,和准确的最终诊断，以确认结节的肿瘤性质。肺肿瘤类型的详细组织学分类和全面的分子表征对于选择有效且针对患者的治疗方法至关重要。然而,在葡萄牙临床组织和国家医疗保健系统的背景下，肺癌患者的理想途径仍然存在一些差距，涉及从缺乏国家肺癌筛查计划到组织学诊断和分子表征方面的困难到治疗方法的挑战。在这份手稿中,我们解决了最相关的弱点，提出了一些改善肺癌患者管理的潜在解决方案的建议，有助于决定性地提高他们的整体生存率和生活质量。
