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Abstract：
BACKGROUND: Sinonasal cancer represents a challenging disease because of its difficult diagnosis and different histology. Despite a multidisciplinary evaluation and treatments, a poor prognosis is still present. We retrospectively analyzed patients with sinonasal cancer treated in our institution, paying attention to histology and real-life prognosis.
METHODS: A total of 51 consecutive patients were included in the study. Clinical features were described. Overall, disease-free, and disease-specific survival (OS, DFS, DSS) according to histology were calculated. Kaplan-Meyer estimator curves were reported.
RESULTS: The most prevalent primary tumor was squamous cell carcinoma, followed by adenocarcinoma. Global 2- and 5-year OS was 68.80% and 54.58%, respectively. Global 2- and 5-year DFS was 48.53% and 29.56%, while global 2- and 5-year DSS was 82.86% and 74.57%, respectively. The median OS was 74 and 43 months for early- and late-stage cancer, respectively. The Cox multivariate regression analysis did not reveal any statistically significant effects of age, stage, or histology on survival outcomes.
CONCLUSIONS: The diagnosis is often late and the prognosis poor. An appropriate treatment, which is always quite multimodal, allows us to achieve a global 5-year OS slightly higher than 50%. An adequate diagnosis to increase the percentage of early-stage tumors is mandatory to improve prognosis.
METHODS: A total of 51 consecutive patients were included in the study. Clinical features were described. Overall, disease-free, and disease-specific survival (OS, DFS, DSS) according to histology were calculated. Kaplan-Meyer estimator curves were reported.
RESULTS: The most prevalent primary tumor was squamous cell carcinoma, followed by adenocarcinoma. Global 2- and 5-year OS was 68.80% and 54.58%, respectively. Global 2- and 5-year DFS was 48.53% and 29.56%, while global 2- and 5-year DSS was 82.86% and 74.57%, respectively. The median OS was 74 and 43 months for early- and late-stage cancer, respectively. The Cox multivariate regression analysis did not reveal any statistically significant effects of age, stage, or histology on survival outcomes.
CONCLUSIONS: The diagnosis is often late and the prognosis poor. An appropriate treatment, which is always quite multimodal, allows us to achieve a global 5-year OS slightly higher than 50%. An adequate diagnosis to increase the percentage of early-stage tumors is mandatory to improve prognosis.
摘要：
背景：由于其诊断困难和组织学不同，鼻窦癌代表了一种具有挑战性的疾病。尽管进行了多学科评估和治疗，预后不良仍然存在.我们回顾性分析了在我们机构治疗的鼻窦肿瘤患者，注意组织学和现实生活中的预后。
方法：共纳入51例连续患者。描述了临床特征。总的来说,无病,和疾病特异性生存率(OS，DFS,DSS)根据组织学进行计算。报告了Kaplan-Meyer估计曲线。
结果：最常见的原发肿瘤是鳞状细胞癌，其次是腺癌。全球2年和5年操作系统分别为68.80%和54.58%，分别。全球2年和5年DFS分别为48.53%和29.56%，而全球2年期和5年期DSS分别为82.86%和74.57%，分别。早期和晚期癌症的中位OS分别为74个月和43个月，分别。Cox多元回归分析未显示年龄的任何统计学显着影响，舞台,或组织学对生存结果的影响。
结论：诊断通常较晚，预后较差。适当的治疗,这总是非常多模态的，使我们能够实现略高于50%的全球5年操作系统。为了改善预后，必须进行适当的诊断以增加早期肿瘤的百分比。
方法：共纳入51例连续患者。描述了临床特征。总的来说,无病,和疾病特异性生存率(OS，DFS,DSS)根据组织学进行计算。报告了Kaplan-Meyer估计曲线。
结果：最常见的原发肿瘤是鳞状细胞癌，其次是腺癌。全球2年和5年操作系统分别为68.80%和54.58%，分别。全球2年和5年DFS分别为48.53%和29.56%，而全球2年期和5年期DSS分别为82.86%和74.57%，分别。早期和晚期癌症的中位OS分别为74个月和43个月，分别。Cox多元回归分析未显示年龄的任何统计学显着影响，舞台,或组织学对生存结果的影响。
结论：诊断通常较晚，预后较差。适当的治疗,这总是非常多模态的，使我们能够实现略高于50%的全球5年操作系统。为了改善预后，必须进行适当的诊断以增加早期肿瘤的百分比。
