PDF(Pubmed)
Abstract：
Acute kidney injury represents a significant threat in cardiac surgery regarding complications and costs. Novel preventive approaches are needed, as the therapeutic modalities are still limited. As experimental studies have demonstrated, glutamine, a conditionally essential amino acid, might have a protective role in this setting. Moreover, the levels of glutamine after the cardiopulmonary bypass are significantly lower. In clinical practice, various trials have investigated the effects of glutamine supplementation on cardiac surgery with encouraging results. However, these studies are heterogeneous regarding the selection criteria, timing, dose, outcomes studied, and way of glutamine administration. This narrative review aims to present the potential role of glutamine in cardiac surgery-associated acute kidney injury prevention, starting from the experimental studies and guidelines to the clinical practice and future directions.
摘要：
在心脏手术中，急性肾损伤对并发症和费用构成重大威胁。需要新的预防方法，因为治疗方式仍然有限。实验研究表明,谷氨酰胺,一种有条件的必需氨基酸，在此设置中可能具有保护作用。此外，体外循环后谷氨酰胺水平显著降低。在临床实践中,各种试验研究了补充谷氨酰胺对心脏手术的影响，并取得了令人鼓舞的结果。然而,这些研究在选择标准上是不同的，定时,剂量,研究结果，和谷氨酰胺的给药方式。这篇叙述性综述旨在介绍谷氨酰胺在心脏手术相关急性肾损伤预防中的潜在作用。从实验研究和指南开始，到临床实践和未来方向。
