Abstract:
Metastatic colorectal cancer requires a multidisciplinary and individualized approach. Herein, we reported the case of a young woman diagnosed with metastatic rectal cancer who received an individualized multimodal treatment strategy that resulted in a remarkable survival. There were several particular aspects of this case, such as the early onset of the disease, the successful use of conversion therapy, the application of liquid biopsy to guide treatment, and the specific nature of the bone metastasis. To offer more insights for navigating such challenges in patients with metastatic colorectal cancer, we have conducted a literature review to find more data related to the particularities of this case. The incidence of early onset colorectal cancer is on the rise. Data suggests that it differs from older-onset colorectal cancer in terms of its pathological, epidemiological, anatomical, metabolic, and biological characteristics. Conversion therapy and surgical intervention provide an opportunity for cure and improve outcomes in metastatic colorectal cancer. It is important to approach each case individually, as every patient with limited liver disease should be considered as a candidate for secondary resection. Moreover, liquid biopsy has an important role in the individualized management of metastatic colorectal cancer patients, as it offers additional information for treatment decisions.
摘要:
转移性结直肠癌需要多学科和个性化的方法。在这里,我们报道了1例年轻女性被诊断为转移性直肠癌,该女性接受了个体化多模式治疗策略,获得了显著的生存率.这个案子有几个特别的方面,比如疾病的早期发作,转换疗法的成功使用,液体活检指导治疗的应用,以及骨转移的特异性。为转移性结直肠癌患者应对这些挑战提供更多见解,我们进行了文献综述,以找到更多与此病例的特殊性相关的数据。早发性结直肠癌的发病率呈上升趋势。数据表明,它在病理方面与老年结直肠癌不同,流行病学,解剖学,新陈代谢,和生物学特征。转换治疗和手术干预为转移性结直肠癌的治愈和改善预后提供了机会。重要的是要单独处理每种情况,因为每一位局限性肝病患者都应被视为二次切除的候选人.此外,液体活检在转移性结直肠癌患者的个体化治疗中具有重要作用,因为它为治疗决策提供了额外的信息。