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Abstract：
While the pathology of acute hemorrhagic fever with renal syndrome (HFRS) has been widely researched, details on the chronic HFRS sequelae remain mainly unexplored. In this study, we analyzed the clinical and laboratory characteristics of 30 convalescent HFRS patients 14 years after the disease contraction, mainly emphasizing several endothelial dysfunction parameters. Convalescent HFRS patients exhibited significantly higher serum levels of erythrocyte sedimentation rate, von Willebrand factor, uric acid, C-reactive protein and immunoglobulin A when compared to healthy individuals. Furthermore, 24 h urine analyses revealed significantly lower sodium and potassium urine levels, as well as significantly higher proteinuria, microalbumin levels and β2-microglobulin levels when compared to healthy individuals. First morning urine analysis revealed significantly higher levels of hematuria in convalescent HFRS patients. None of the additional analyzed endothelium dysfunction markers were significantly different in post-HFRS patients and healthy individuals, including serum and urine P-selectin, E-selectin, soluble intercellular adhesion molecule 1, vascular intercellular adhesion molecule 1 (sVCAM-1) and vascular endothelial growth factor (VEGF). However, binary logistic regression revealed a weak association of serum sVCAM-1 and urine VEGF levels with HFRS contraction. Generally, our findings suggest mild chronic inflammation and renal dysfunction levels in convalescent HFRS patients 14 years after the disease contraction.
摘要：
虽然对急性肾综合征出血热(HFRS)的病理学研究较多,关于慢性HFRS后遗症的细节仍未被研究。在这项研究中,我们分析了30例恢复期HFRS患者在疾病收缩后14年的临床和实验室特征，主要强调几种内皮功能障碍参数。恢复期HFRS患者血清血沉水平明显增高,vonWillebrand因子,尿酸,与健康个体相比时的C反应蛋白和免疫球蛋白A。此外，24小时尿液分析显示钠和钾尿液水平显着降低，以及明显较高的蛋白尿，与健康个体相比，微量白蛋白水平和β2-微球蛋白水平。第一天早上的尿液分析显示，康复期HFRS患者的血尿水平显着升高。在HFRS后患者和健康个体中，没有其他分析的内皮功能障碍标志物存在显着差异，包括血清和尿液P-选择素，E-选择素,可溶性细胞间粘附分子1、血管细胞间粘附分子1(sVCAM-1)和血管内皮生长因子(VEGF)。然而,二元logistic回归分析显示血清sVCAM-1和尿液VEGF水平与HFRS收缩之间存在弱关联.一般来说,我们的研究结果提示恢复期HFRS患者在疾病收缩14年后出现轻度慢性炎症和肾功能不全.
