PDF(Pubmed)
Abstract：
Background: Varicocele still today represents a common cause of infertility in young men. The treatment strategy remains a surgical approach such as scleroembolization; however, the complete restoration of spermatic parameters afterward requires an average of six or more months to fully regain optimal seminal parameters. Recently, many studies have demonstrated the beneficial effects of Resveratrol in male fertility, given its potential anti-inflammatory, antiapoptotic, and mitochondrial effects. Therefore, Resveratrol-based nutraceuticals could be promising as an adjuvant to mitigate subfertility in patients with varicocele. Methods: In the present study, we retrospectively analyzed the effects of the administration of a Resveratrol-based nutraceutical after the scleroembolization procedure. The improvement of sperm quality in terms of number, motility, and morphology were considered to be the study\'s main endpoints. A spreadsheet program was used for data analysis, and a p-value of <0.05 was considered significant. Results: We found a statistically significant improvement in the spermatic parameters (sperm count and total motility) and an increase in normal sperm after only 4 months of treatment. The supplementation with a Resveratrol-based nutraceutical associated with the surgical procedure showed encouraging results if compared to data from a control group and the results reported in the literature linked to scleroembolization practice alone. In fact, there was a clear improvement in the seminal parameters at 4 months. Conclusions: This suggests the positive impact of the Resveratrol-based nutraceutical in synergizing with scleroembolization in reducing the time needed to fully recover sperm function.
摘要：
背景：精索静脉曲张今天仍然是年轻男性不育的常见原因。治疗策略仍然是手术方法，如硬化栓塞；然而，之后精索参数的完全恢复平均需要六个月或更长时间才能完全恢复最佳精索参数。最近,许多研究证明了白藜芦醇对男性生育能力的有益作用，鉴于其潜在的抗炎作用，抗凋亡，和线粒体效应。因此,白藜芦醇为基础的营养保健品有望作为一种佐剂，以减轻精索静脉曲张患者的不孕症。方法：在本研究中，我们回顾性分析了硬化栓塞手术后给予白藜芦醇类营养药物的效果.精子质量在数量上的提高，运动性,和形态学被认为是研究的主要终点。使用电子表格程序进行数据分析，P值<0.05被认为是显著的。结果：我们发现仅治疗4个月后，精子参数（精子数量和总运动性）有统计学上的显着改善，正常精子增加。如果与对照组的数据以及文献中报道的与硬化栓塞实践相关的结果相比，与外科手术相关的基于白藜芦醇的营养保健品的补充显示出令人鼓舞的结果。事实上,4个月时,精液参数有明显改善.结论：这表明基于白藜芦醇的营养药物在与硬化栓塞协同作用中的积极影响，以减少完全恢复精子功能所需的时间。
