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Abstract：
Background: Chemotherapy is a common treatment for pediatric cancer. Although life prognosis is improving because of advances in medical science, it is important to deal with late effects such as dental abnormalities. We investigated the association between dental abnormalities and chemotherapy by age and tooth type. Methods: Among the 568 patients referred to the pediatric dentistry department of our hospital, we selected 32 patients (21 male and 11 female) who received chemotherapy between the ages of 0 and 6 and underwent panoramic examination after the age of 7. We recorded the age of chemotherapy commencement, diagnosis of systemic disease, and dental abnormalities such as congenital absence, microdonts, and short-rooted teeth. Results: Almost half of the patients had dental abnormalities such as congenital absence, microdonts, and short-rooted teeth, but there were no significant differences in the incidence of these abnormalities by age. When we analyzed the incidence of abnormal teeth by tooth type, the incidence of congenital absence was significantly higher in premolars (5.5%) and second molars (3.9%) than in incisor or canine or 1st molar (0.4%) (p < 0.01). The incidence of microdonts was significantly higher in premolars (3.9%) than in incisor or canine or 1st molar (0.2%) and second molars (0.0%) (p < 0.05). Conclusions: Patients who received chemotherapy had a high prevalence of dental abnormalities, and the incidence of abnormalities varied by tooth type. It is important to maintain long-term oral care for patients who have undergone chemotherapy even after the treatment is completed.
摘要：
背景：化疗是儿科癌症的常用治疗方法。尽管由于医学科学的进步，生活预后正在改善，处理牙齿异常等晚期影响很重要。我们根据年龄和牙齿类型调查了牙齿异常与化疗之间的关系。方法:在我院儿童口腔科转诊的568例患者中,我们选择了32例患者(男21例,女11例),这些患者在0~6岁之间接受化疗,7岁之后接受全景检查.我们记录了化疗开始的年龄,全身性疾病诊断，和牙齿异常，如先天性缺失，microdonts,和短根牙齿。结果：几乎一半的患者有牙齿异常，如先天性缺失，microdonts,和短根牙齿，但是这些异常的发生率按年龄没有显着差异。当我们按牙齿类型分析异常牙齿的发生率时，先天性缺失的发生率在前磨牙（5.5％）和第二磨牙（3.9％）明显高于切牙，犬齿或第一磨牙（0.4％）（p<0.01）。前磨牙（3.9％）的微牙发生率明显高于门牙或犬牙或第一磨牙（0.2％）和第二磨牙（0.0％）（p<0.05）。结论：接受化疗的患者牙齿异常的患病率很高，异常的发生率因牙齿类型而异。即使在治疗完成后，对接受化疗的患者保持长期口腔护理也很重要。
