PDF(Pubmed)
Abstract：
(1) Background: Patients with Fuchs\' endothelial corneal dystrophy (FECD) may have coexisting cataracts and, therefore, may require a cataract surgery, which poses challenges due to potential endothelial cell damage. FECD is a degenerative eye disease of unclear etiology, with inflammatory cytokines maybe playing an important role in its development and progression. The present study aimed to investigate the cytokine profile in the aqueous humor of FECD eyes with cataract. (2) Methods: Fifty-two patients were included in the study, 26 with FECD + cataract and 26 with cataract as a control group. Samples of the aqueous humor were analyzed for pro- and anti-inflammatory cytokines using a Bio-Plex 200 system. (3) Results: Interleukin 1 receptor antagonist (IL-1Ra) and interleukin IL-8 levels were significantly higher in the aqueous humor of FECD + cataract patients compared to the control/cataract group. Moreover, the levels of anti-inflammatory IL-10 showed a strong trend to be higher in the FECD + cataract group compared to the control group. In contrast, there were no statistically significant differences in IL-1β, IL-6, IL-4, IL-10, IL-13, IL-17A, and tumor necrosis factor TNF-α between the groups. (4) Conclusions: Presented research contributes to a better understanding of FECD pathogenesis. Elevated levels of IL-1Ra and IL-8 may serve as a defense mechanism in people with FECD and coexisting cataract.
摘要：
(1)背景:Fuchs内皮角膜营养不良(FECD)患者可能合并白内障,因此,可能需要白内障手术，由于潜在的内皮细胞损伤，这带来了挑战。FECD是一种病因不明的退行性眼病，炎性细胞因子可能在其发生发展中起重要作用。本研究旨在研究患有白内障的FECD眼房水中的细胞因子谱。(2)方法:52例患者纳入研究,26以FECD+白内障和26以白内障为对照组。使用Bio-Plex200系统分析房水样品的促炎和抗炎细胞因子。(3)结果:与对照组/白内障组相比,FECD+白内障患者房水白细胞介素1受体拮抗剂(IL-1Ra)和白细胞介素IL-8水平明显增高。此外，与对照组相比,FECD+白内障组的抗炎IL-10水平呈较高趋势.相比之下,IL-1β无统计学差异,IL-6、IL-4、IL-10、IL-13、IL-17A、各组间肿瘤坏死因子TNF-α。(4)结论：本研究有助于更好地理解FECD的发病机制。IL-1Ra和IL-8水平的升高可能是患有FECD和共存白内障的人的防御机制。
