PDF(Pubmed)
Abstract：
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation.
摘要：
促生长素抑制素受体2型（SSTR2）的过表达是各种肿瘤类型的特性。利用[68Ga]1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA)的混合成像可以改善肿瘤和健康组织之间的分化。我们对47例匿名患者进行了实验研究，其中包括30例脑膜瘤，12PitNET和5SBPGL。指示四名独立观察者在计划MRI时绘制宏观肿瘤体积的轮廓，然后使用DOTA-PET/CT的其他信息重新评估其体积。评估了观察者和参考卷之间的一致性。总的来说,46例（97.9％）是DOTA-狂热，并包括在最终分析中。在八个案例中，PET/CT识别出MRI未检测到的额外肿瘤体积；这些PET/CT发现对于4例患者的治疗计划可能至关重要。对于脑膜瘤，PET/CT的观察者和观察者对参考体积的一致性指数较高。对于PitNET，MRI观察者之间的体积一致性较高.关于SBGDL，未观察到与添加PET/CT信息相符的显著趋势.DOTAPET/CT支持脑膜瘤和PitNET中的准确肿瘤识别，并建议在计划使用高度适形放射治疗的表达SSTR2的肿瘤中使用。
