PDF(Pubmed)
Abstract：
French Guiana is a French territory in South America. The exposome of persons living there is quite different from that in mainland France and the ethnic make-up of the population is also quite different. Poverty is also widespread with difficulties in accessing care magnified by the low medical-professional density. In this singular context, we aimed to measure the incidence of pediatric cancers and to compare it with other continents. We used French Guiana\'s certified cancer registry to study this between 2003 and 2017. Incidences were standardized using the world population with three strata: 0-4 years, 5-9 years, and 10-14 years. There were 164 solid tumors or hematologic malignancies diagnosed in children under the age of 15 (92 in boys and 72 in girls). Over the study period, the standardized incidence rate was 14.1 per 100,000 among children aged under 15 years. There was no significant trend during the study period. The three most common causes of cancer were leukemias-mostly lymphoblastic-CNS tumors, and sarcoma. The standardized incidence of pediatric cancers in French Guiana was similar to those in Western Europe and North America. As others have discovered, we found that males tended to be more likely to develop cancer, notably leukemia, CNS tumors, sarcoma, and retinoblastoma. As elsewhere, the predominant cancer types changed with age. Our initial assumption was that given the singular context of French Guiana, there may have been differences in pediatric cancer incidences. Here we showed that overall, contrary to our assumption and to trends in tropical countries, the incidence of pediatric cancers was in a range between Western Europe and North America with some apparent but non-significant differences in the main types of cancers observed in global statistics. Quality cancer registry data in this tropical region confirm the suspicion that lower incidences in tropical low- and middle-income countries are likely to result from incomplete diagnosis and data collection.
摘要：
法属圭亚那是法国在南美洲的领土。居住在那里的人与法国大陆的人有很大不同，人口的种族构成也有很大不同。贫困也很普遍，由于医疗专业密度低，难以获得护理。在这个奇异的背景下，我们的目的是测量儿童癌症的发病率，并将其与其他大洲进行比较。我们在2003年至2017年之间使用法属圭亚那认证的癌症登记处进行了研究。发病率使用三个阶层的世界人口进行标准化：0-4岁，5-9年,和10-14年。在15岁以下的儿童中诊断出164例实体瘤或血液系统恶性肿瘤（男孩92例，女孩72例）。在学习期间，15岁以下儿童的标准化发病率为每100,000人中14.1人.在研究期间没有显著的趋势。癌症的三个最常见的原因是白血病-主要是淋巴母细胞-中枢神经系统肿瘤，和肉瘤.法属圭亚那儿科癌症的标准化发病率与西欧和北美相似。正如其他人所发现的，我们发现男性更容易患癌症，尤其是白血病,中枢神经系统肿瘤，肉瘤,和视网膜母细胞瘤.和其他地方一样,主要的癌症类型随着年龄的增长而变化。我们最初的假设是，鉴于法属圭亚那的独特背景，儿科癌症发病率可能存在差异。在这里，我们展示了总的来说，与我们的假设和热带国家的趋势相反，儿科癌症的发病率在西欧和北美之间有一定的范围,在全球统计中观察到的主要癌症类型之间存在一些明显但不显著的差异.该热带地区的高质量癌症登记数据证实了这样一种怀疑，即热带低收入和中等收入国家的发病率较低可能是由于诊断和数据收集不完整所致。
