PDF(Pubmed)
Abstract：
The primary objective of this study was to demonstrate the non-inferiority between lidocaine-impregnated ligation bands (LLBs) and control bands (CBs) with respect to the efficacy of castration and tail docking. Secondary objectives were to compare castration and tail-docking success, evaluate local site reactions, and compare average daily gain (ADG) between the treatment groups. A total of 238 male lambs were enrolled and randomly assigned to receive LLBs or CBs on their tail and scrotum. Lambs were weighed, had a health assessment, and the band site was observed on -3, 7, 14, 21, 28, 35, and 42 days after the bands were applied. A linear regression model was built to assess average daily gain, whereas a repeated measures model was used to evaluate body weight differences at each of the measured timepoints. Furthermore, logistic regression models were used to evaluate associations with casting outcomes. Few differences were noted between treatment groups with respect to casting success for the scrotum and tail and ADG over the entire experimental period. Non-inferiority calculations demonstrated no differences in tail docking and scrotal casting success, with casting occurring for the majority of animals by d 21 and d 42 for castration and tail docking, respectively. However, lambs receiving LLBs gained more weight from d -3 to 7 (+0.03 kg/d; 95% CI: 0 to 0.07), which may be an indication of effective pain control during the first week following band application. Overall, the use of an LLB does not affect the time to successful casting of the tail and could improve short-term growth when compared to a control band. Further studies are needed to compare LLBs to multimodal methods of pain relief.
摘要：
这项研究的主要目的是证明利多卡因浸渍的结扎带（LLB）和对照带（CB）之间在去势和尾部对接功效方面的非劣效性。次要目标是比较去势和尾部对接成功，评估局部反应，并比较治疗组之间的平均日增重（ADG）。总共招募了238只雄性羔羊，并随机分配在其尾巴和阴囊上接受LLB或CB。给羔羊称重,有健康评估，并且在施用条带后的-3、7、14、21、28、35和42天观察到条带部位。建立了线性回归模型来评估平均日增重，而重复测量模型用于评估每个测量时间点的体重差异.此外，使用logistic回归模型评估与铸造结果的关联.在整个实验期间，在阴囊和尾巴以及ADG的铸造成功方面，治疗组之间几乎没有差异。非劣效性计算表明，尾部对接和阴囊铸造成功没有差异，在第21天和第42天，大多数动物都进行了去势和尾部对接的铸造，分别。然而,接受LLB的羔羊从d-3增加到7(+0.03kg/d;95%CI:0到0.07)，这可能是在应用带之后的第一周内有效控制疼痛的迹象。总的来说,与对照带相比，LLB的使用不会影响成功投射尾部的时间，并且可以改善短期生长。需要进一步的研究来比较LLB与缓解疼痛的多模式方法。
