PDF(Pubmed)
Abstract：
Gap junctions (GJs) are important in the regulation of cell growth, morphology, differentiation and migration. However, recently, more attention has been paid to their role in the pathogenesis of different diseases as well as tumorigenesis, invasion and metastases. The expression pattern and possible role of connexins (Cxs), as major GJ proteins, under both physiological and pathological conditions in the adrenal gland, were evaluated in this review. The databases Web of Science, PubMed and Scopus were searched. Studies were evaluated if they provided data regarding the connexin expression pattern in the adrenal gland, despite current knowledge of this topic not being widely investigated. Connexin expression in the adrenal gland differs according to different parts of the gland and depends on ACTH release. Cx43 is the most studied connexin expressed in the adrenal gland cortex. In addition, Cx26, Cx32 and Cx50 were also investigated in the human adrenal gland. Cx50 as the most widespread connexin, along with Cx26, Cx29, Cx32, Cx36 and Cx43, has been expressed in the adrenal medulla with distinct cellular distribution. Considerable effort has recently been directed toward connexins as therapeutically targeted molecules. At present, there exist several viable strategies in the development of potential connexin-based therapeutics. The differential and hormone-dependent distribution of gap junctions within adrenal glands, the relatively large gap junction within this gland and the increase in the gap junction size and number following hormonal treatment would indicate that gap junctions play a pivotal role in cell functioning in the adrenal gland.
摘要：
间隙连接(GJs)在调节细胞生长中起着重要作用,形态学,分化和迁移。然而,最近,它们在不同疾病的发病机制以及肿瘤发生中的作用越来越受到重视，侵袭和转移。连接蛋白（Cxs）的表达模式和可能的作用，作为主要的GJ蛋白，在肾上腺的生理和病理条件下，在这篇综述中进行了评估。WebofScience数据库,搜索了PubMed和Scopus。评估研究是否提供了有关肾上腺连接蛋白表达模式的数据，尽管目前对该主题的了解尚未得到广泛研究。肾上腺中的连接蛋白表达根据腺体的不同部分而不同，并取决于ACTH释放。Cx43是在肾上腺皮质中表达最多的研究连接蛋白。此外,还在人肾上腺中研究了Cx26、Cx32和Cx50。Cx50是最广泛的连接蛋白，与Cx26，Cx29，Cx32，Cx36和Cx43一起，已在肾上腺髓质中表达，具有不同的细胞分布。最近已经针对作为治疗靶向分子的连接蛋白进行了相当大的努力。目前,在潜在的基于连接蛋白的治疗方法的开发中存在几种可行的策略.肾上腺缝隙连接的差异和激素依赖性分布，该腺体内相对较大的间隙连接以及激素治疗后间隙连接大小和数量的增加表明间隙连接在肾上腺细胞功能中起关键作用。
