PDF(Pubmed)
Abstract：
In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal tissue damage. Since most tissue adhesives are designed for internal use or wound treatments, the biodegradation of adhesives is important. To endow tissue adhesives with biodegradability, in the past few decades, various biodegradable polymers, either natural polymers (such as chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, and peptides) or synthetic polymers (such as poly(lactic acid), polyurethanes, polycaprolactone, and poly(lactic-co-glycolic acid)), have been utilized to develop novel biodegradable tissue adhesives. Incorporated biodegradable polymers are degraded in vivo with time under specific conditions, leading to the destruction of the structure and the further degradation of tissue adhesives. In this review, we first summarize the strategies of utilizing biodegradable polymers to develop tissue adhesives. Furthermore, we provide a symmetric overview of the biodegradable polymers used for tissue adhesives, with a specific focus on the degradability and applications of these tissue adhesives. Additionally, the challenges and perspectives of biodegradable polymer-based tissue adhesives are discussed. We expect that this review can provide new inspirations for the design of novel biodegradable tissue adhesives for biomedical applications.
摘要：
在临床实践中,由于其易于使用的优势，组织粘合剂已成为伤口治疗的替代工具，快速应用,更少的痛苦，和最小的组织损伤。由于大多数组织粘合剂设计用于内部使用或伤口治疗，粘合剂的生物降解是重要的。为了赋予组织粘合剂可生物降解性，在过去的几十年里，各种可生物降解的聚合物，无论是天然聚合物(如壳聚糖，透明质酸，明胶,硫酸软骨素，淀粉，海藻酸钠,葡聚糖,果胶,功能蛋白,和肽）或合成聚合物（例如聚（乳酸），聚氨酯，聚己内酯,和聚（乳酸-羟基乙酸共聚物），已被用于开发新的可生物降解的组织粘合剂。掺入的生物可降解聚合物在特定条件下随时间在体内降解，导致结构的破坏和组织粘合剂的进一步降解。在这次审查中,我们首先总结了利用生物可降解聚合物开发组织粘合剂的策略。此外，我们提供了用于组织粘合剂的可生物降解聚合物的对称概述，特别关注这些组织粘合剂的降解性和应用。此外,讨论了基于可生物降解聚合物的组织粘合剂的挑战和前景。我们期望这篇综述可以为生物医学应用的新型生物可降解组织粘合剂的设计提供新的启示。
