PDF(Pubmed)
Abstract：
Cardiovascular diseases, among which includes coronary artery disease, represent one of the most important causes of mortality and morbidity worldwide. Research aimed at determining the risk factors involved recognizes a group of \"traditional\" risk factors, but also more recent studies identified over 100 \"novel\" ones which may have a role in the disease. Among the latter is the thrombophilia profile of a patient, a pathology well-established for its involvement in venous thromboembolism, but with less studied implications in arterial thrombosis. This paper reviews the literature, explaining the pathophysiology of the thrombophilia causes associated most with coronary thrombosis events. Results of several studies on the subject, including a meta-analysis with over 60,000 subjects, determined the significant involvement of factor V Leiden, prothrombin G20210A mutation, plasminogen activator inhibitor-1 and antiphospholipid syndrome in the development of coronary artery disease. The mechanisms involved are currently at different stages of research, with some already established and used as therapeutic targets.
摘要：
心血管疾病,其中包括冠状动脉疾病，是全球死亡率和发病率的最重要原因之一。旨在确定所涉及的风险因素的研究认识到一组“传统”风险因素，但最近的研究也确定了超过100个可能在这种疾病中起作用的“新”。后者是患者的血栓形成倾向，一种因参与静脉血栓栓塞而确立的病理学，但在动脉血栓形成方面研究较少。本文回顾了文献，解释与冠状动脉血栓形成事件最相关的血栓形成倾向的病理生理学原因。关于这个问题的几项研究的结果，包括对超过60,000名受试者的荟萃分析，确定因子V莱顿的显著参与，凝血酶原G20210A突变,纤溶酶原激活物抑制剂-1和抗磷脂综合征在冠状动脉疾病发展中的作用。所涉及的机制目前处于不同的研究阶段，其中一些已经建立并用作治疗靶标。
