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Abstract：
Periodontitis is linked to the onset and progression of oral squamous cell carcinoma (OSCC), an epidemiologically frequent and clinically aggressive malignancy. In this context, Fusobacterium (F.) nucleatum and Porphyromonas (P.) gingivalis, two bacteria that cause periodontitis, are found in OSCC tissues as well as in oral premalignant lesions, where they exert pro-tumorigenic activities. Since the two bacteria are present also in endodontic diseases, playing a role in their pathogenesis, here we analyze the literature searching for information on the impact that endodontic infection by P. gingivalis or F. nucleatum could have on cellular and molecular events involved in oral carcinogenesis. Results from the reviewed papers indicate that infection by P. gingivalis and/or F. nucleatum triggers the production of inflammatory cytokines and growth factors in dental pulp cells or periodontal cells, affecting the survival, proliferation, invasion, and differentiation of OSCC cells. In addition, the two bacteria and the cytokines they induce halt the differentiation and stimulate the proliferation and invasion of stem cells populating the dental pulp or the periodontium. Although most of the literature confutes the possibility that bacteria-induced endodontic inflammatory diseases could impact on oral carcinogenesis, the papers we have analyzed and discussed herein recommend further investigations on this topic.
摘要：
牙周炎与口腔鳞状细胞癌（OSCC）的发生和发展有关，流行病学上常见且临床上具有侵袭性的恶性肿瘤。在这种情况下，梭杆菌(F.)核子和卟啉虫(P.)牙龈,两种引起牙周炎的细菌，在OSCC组织以及口腔癌前病变中发现，在那里他们发挥促肿瘤活性。由于这两种细菌也存在于牙髓疾病中，在他们的发病机制中发挥作用，在这里，我们分析了有关牙龈卟啉单胞菌或核仁F.的牙髓感染可能对口腔癌变相关的细胞和分子事件的影响的文献。综述论文的结果表明，牙龈卟啉单胞菌和/或核仁F.的感染会触发牙髓细胞或牙周细胞中炎性细胞因子和生长因子的产生，影响生存，扩散,入侵,和OSCC细胞的分化。此外,这两种细菌及其诱导的细胞因子停止分化，并刺激填充牙髓或牙周组织的干细胞的增殖和侵袭。尽管大多数文献都否认细菌诱导的牙髓炎性疾病可能影响口腔癌的可能性，我们在此分析和讨论的论文建议对此主题进行进一步研究。
