PDF(Pubmed)
Abstract：
The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid P-oxidation in the liver across different ethnic/racial groups. The sensitivity and specificity of pharmacogenetic testing panels for predicting the rate of metabolism of valproic acid by P-oxidation can be increased by prioritizing the inclusion of the most common risk allele characteristic of a particular population (country).
摘要：
精神药品使用的安全性,广泛用于神经和精神病学实践，是个性化医疗中一个亟待解决的问题。这篇叙述性综述表明，不同种族/种族的肝脏中编码丙戊酸P氧化关键同工酶的基因中，低功能和非功能单核苷酸变体的等位基因频率存在差异。通过优先考虑特定人群（国家）最常见的风险等位基因特征，可以提高药物遗传学测试小组预测P-氧化丙戊酸代谢率的敏感性和特异性。
