PDF(Pubmed)
Abstract：
Extracellular vesicles represent a group of structures with the capacity to communicate with different cells and organs. This complex network of interactions can regulate multiple physiological processes in the organism. Very importantly, these processes can be altered during the appearance of different diseases including cancer, metabolic diseases, etc. In addition, these extracellular vesicles can transport different cargoes, altering the initiation of the disease, driving the progression, or even accelerating the pathogenesis. Then, we have explored the implication of these structures in different alterations such as pancreatic cancer, and in different metabolic alterations such as diabetes and its complications and non-alcoholic fatty liver disease. Finally, we have explored in more detail the communication between the liver and the pancreas. In summary, extracellular vesicles represent a very efficient system for the communication among different tissues and permit an efficient system as biomarkers of the disease, as well as being involved in the extracellular-vesicle-mediated transport of molecules, serving as a potential therapy for different diseases.
摘要：
细胞外囊泡代表一组具有与不同细胞和器官通信能力的结构。这种复杂的相互作用网络可以调节生物体中的多个生理过程。非常重要的是,这些过程可以在包括癌症在内的不同疾病的出现过程中改变，代谢性疾病，等。此外,这些细胞外囊泡可以运输不同的货物，改变疾病的开始，推动进步，甚至加速发病。然后，我们已经探索了这些结构在不同改变中的意义，例如胰腺癌，以及不同的代谢改变，如糖尿病及其并发症和非酒精性脂肪性肝病。最后,我们更详细地探讨了肝脏和胰腺之间的交流。总之,细胞外囊泡代表了一个非常有效的系统，用于不同组织之间的通信，并允许一个有效的系统作为疾病的生物标志物，以及参与细胞外囊泡介导的分子转运，作为不同疾病的潜在疗法。
