PDF(Pubmed)
Abstract：
The platelet-rich plasma (PRP) approach may be an effective treatment for joint and cartilage pathologies. However, the rationale for its effectiveness on joint instability is limited. This study aimed to assess the safety and effectiveness of PRP injections in patients with chronic lateral ankle instability (CLAI). This retrospective study was performed at a single-center outpatient clinic between January 2015 and February 2023 and included pre-intervention assessment and short-term follow-up. Patients were excluded if they had received previous surgical treatment or had constitutional hyperlaxity, systemic diseases, or grade II or III osteoarthritis. The clinical and functional evaluation consisted of the Karlsson score, the Cumberland Ankle Instability Tool (CAIT), Good\'s grading system, the patient\'s subjective satisfaction level, and the time required to return to exercise. The entire PRP therapy regime consisted of three PRP administrations at 7-day intervals and follow-up appointments. PRP was administered both intraarticularly and into talofibular ligaments. A total of 47 consecutive patients with CLAI were included, 11 were female (23.4%), with a mean age at intervention of 31.19 ± 9.74 years. A statistically significant improvement was found in the CAIT and Karlsson scores at 3 months (27.74 ± 1.68 and 96.45 ± 4.28, respectively) relative to the pre-intervention status (10.26 ± 4.33 and 42.26 ± 14.9, respectively, p < 0.000). The mean follow-up of patients with CLAI was 17.94 ± 3.25 weeks. This study represents successful short-term functional and clinical outcomes in patients with CLAI after PRP treatment, with no adverse effects. It demonstrates the feasibility of a randomized controlled trial to further assess this therapy.
摘要：
富血小板血浆（PRP）方法可能是关节和软骨病变的有效治疗方法。然而,其对关节不稳定的有效性的理由是有限的。这项研究旨在评估PRP注射在慢性踝关节外侧不稳定（CLAI）患者中的安全性和有效性。这项回顾性研究于2015年1月至2023年2月在单中心门诊进行，包括干预前评估和短期随访。如果患者以前接受过手术治疗或有体质过度松弛，则被排除在外。全身性疾病,或II级或III级骨关节炎。临床和功能评估包括Karlsson评分，坎伯兰脚踝不稳定工具（CAIT），良好的评分系统，患者的主观满意度，以及恢复锻炼所需的时间。整个PRP治疗方案包括间隔7天的三次PRP给药和随访预约。关节内和距腓骨韧带均给予PRP。共纳入47例CLAI患者，11人为女性（23.4%），干预时的平均年龄为31.19±9.74岁。相对于干预前状态（分别为10.26±4.33和42.26±14.9，3个月时的CAIT和Karlsson评分（分别为27.74±1.68和96.45±4.28）有统计学上的显着改善。p<0.000)。CLAI患者的平均随访时间为17.94±3.25周。这项研究代表了PRP治疗后CLAI患者的短期功能和临床结局。没有不良影响。它证明了进一步评估这种疗法的随机对照试验的可行性。
