关键词: chronic pain explant neuromodulation spinal cord stimulator waveform

来  源:   DOI:10.3390/biomedicines12050930   PDF(Pubmed)

Abstract:
Spinal cord stimulation (SCS) is a therapeutic modality for the treatment of various chronic pain conditions that has rapidly evolved over the past 50 years. Unfortunately, over time, patients implanted with SCS undergo a habituation phenomenon leading to decreased pain relief. Consequently, the discovery of new stimulation waveforms and SCS applications has been shown to prolong efficacy and reduce explantation rates. This article explores various SCS waveforms, their applications, and proposes a graded approach to habituation mitigation. We suspect the neural habituation phenomenon parallels that seen in pharmacology. Consequently, we urge further exploration of the early introduction of these stimulation strategies to abate spinal cord stimulation habituation.
摘要:
脊髓刺激(SCS)是一种用于治疗各种慢性疼痛状况的治疗方式,在过去的50年中迅速发展。不幸的是,随着时间的推移,植入SCS的患者经历了导致疼痛缓解减少的习惯现象。因此,新的刺激波形和SCS应用的发现已被证明可以延长疗效并降低外植率。本文探讨了各种SCS波形,他们的应用,并提出了一种分级的习惯缓解方法。我们怀疑神经习惯现象与药理学相似。因此,我们敦促进一步探索早期引入这些刺激策略以减轻脊髓刺激习惯。
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