PDF(Pubmed)
Abstract：
BRCA1 mutations predispose women to breast and ovarian cancer. The anticancer effect of zinc is typically linked to its antioxidant abilities and protecting cells against oxidative stress. Zinc regulates key processes in cancer development, including DNA repair, gene expression, and apoptosis. We took a blood sample from 989 female BRCA1 mutation carriers who were initially unaffected by cancer and followed them for a mean of 7.5 years thereafter. There were 172 incident cases of cancer, including 121 cases of breast cancer, 29 cases of ovarian cancers, and 22 cancers at other sites. A zinc level in the lowest tertile was associated with a modestly higher risk of ovarian cancer compared to women with zinc levels in the upper two tertiles (HR = 1.65; 95% CI 0.80 to 3.44; p = 0.18), but this was not significant. Among those women with zinc levels in the lowest tertile, the 10-year cumulative risk of ovarian cancer was 6.1%. Among those in the top two tertiles of zinc level, the ten-year cumulative risk of ovarian cancer was 4.7%. There was no significant association between zinc level and breast cancer risk. Our preliminary study does not support an association between serum zinc level and cancer risk in BRCA1 mutation carriers.
摘要：
BRCA1突变使女性易患乳腺癌和卵巢癌。锌的抗癌作用通常与其抗氧化能力和保护细胞免受氧化应激有关。锌调节癌症发展的关键过程，包括DNA修复,基因表达，和凋亡。我们采集了989名女性BRCA1突变携带者的血液样本，这些携带者最初未受癌症影响，此后平均随访7.5年。有172例癌症事件，包括121例乳腺癌，29例卵巢癌，和其他部位的22种癌症。与高二等位的女性相比，最低三等位的锌水平与卵巢癌的风险更高相关（HR=1.65;95％CI0.80至3.44;p=0.18），但这并不重要。在那些锌含量最低的女性中，卵巢癌的10年累积风险为6.1%.在锌水平最高的两个三分位数中，卵巢癌的10年累积风险为4.7%.锌水平与乳腺癌风险之间没有显着关联。我们的初步研究不支持BRCA1突变携带者血清锌水平与癌症风险之间的关联。
