PDF(Pubmed)
Abstract：
To date, there have been no review articles specifically relating to the general efficacy and safety of coenzyme Q10 (CoQ10) supplementation in younger subjects. In this article, we therefore reviewed the efficacy and safety of CoQ10 supplementation in neonates (less than 1 month of age), infants (up to 1 year of age) and children (up to 12 years of age). As there is no rationale for the supplementation of CoQ10 in normal younger subjects (as there is in otherwise healthy older subjects), all of the articles in the medical literature reviewed in the present article therefore refer to the supplementation of CoQ10 in younger subjects with a variety of clinical disorders; these include primary CoQ10 deficiency, acyl CoA dehydrogenase deficiency, Duchenne muscular dystrophy, migraine, Down syndrome, ADHD, idiopathic cardiomyopathy and Friedreich\'s ataxia.
摘要：
迄今为止,目前还没有专门针对年轻受试者补充辅酶Q10(CoQ10)的一般疗效和安全性的综述文章.在这篇文章中,因此，我们回顾了新生儿（小于1月龄）补充辅酶Q10的疗效和安全性，婴儿（1岁以下）和儿童（12岁以下）。由于在正常的年轻受试者中没有补充CoQ10的理由（如在其他健康的老年受试者中），因此，本文回顾的医学文献中的所有文章都提到了在患有各种临床疾病的年轻受试者中补充辅酶Q10；这些包括原发性辅酶Q10缺乏症，酰基辅酶A脱氢酶缺乏症，杜氏肌营养不良症,偏头痛,唐氏综合症,多动症,特发性心肌病和Friedreich共济失调。
