PDF(Pubmed)
Abstract：
Few randomized controlled trials have reported that repetitive transcranial magnetic stimulation (rTMS) has controversial results for managing multiple domains of fibromyalgia-related symptoms. This work aimed to evaluate the effect of low-frequency rTMS over the right dorsolateral prefrontal area (DLPFC) on the Fibromyalgia Impact Questionnaire (FIQ) concerning psychiatric and cognitive disorders. Forty-two eligible patients with fibromyalgia (FM) were randomized to have 20 sessions of active or sham rTMS (1 Hz, 120% of resting motor threshold with a total of 1200 pules/session) over the right DLPFC. All participants were evaluated at baseline, post sessions, and 3 months after sessions with the FIQ, Hamilton depression, and anxiety rating scales (HDRS and HARS), Montreal Cognitive Assessment (MoCA), Rey Auditory Verbal Learning Test (RAVLT), Tower of London test (TOL), the Trail Making, and Digit Span Tests. Both groups showed improvement in most rating scales at 1 and 3 months follow-up, with greater improvement in the active group, with significant correlation between FIQ cognitive rating scales, including RAVLT and TOL. Twenty sessions of low-frequency rTMS over the right DLPFC can improve FIQ scores regarding the psychiatric and cognitive symptoms of medicated patients with FM to a greater extent than sham. Changes in RAVLT and TOL correlated with changes in FIQ results.
摘要：
很少有随机对照试验报道重复经颅磁刺激（rTMS）在治疗多个领域的纤维肌痛相关症状方面有争议。这项工作旨在评估右背外侧前额叶区域（DLPFC）的低频rTMS对有关精神病和认知障碍的纤维肌痛影响问卷（FIQ）的影响。42名符合条件的纤维肌痛（FM）患者被随机分为20次活动或假rTMS（1Hz，静止运动阈值的120%，总共1200个脉冲/会话)超过右侧DLPFC。所有参与者在基线时进行评估，会议后,在与FIQ会面3个月后，汉密尔顿抑郁症,和焦虑评定量表(HDRS和HARS)，蒙特利尔认知评估（MoCA）Rey听觉语言学习测试（RAVLT），伦敦塔测试（TOL），跟踪制作，和数字跨度测试。两组在随访1个月和3个月时大多数评分量表均有改善，随着活跃群体的进步，FIQ认知评定量表之间具有显著的相关性，包括RAVLT和TOL。在正确的DLPFC上进行二十次低频rTMS可以比假手术更大程度地改善FM药物患者的精神和认知症状的FIQ得分。RAVLT和TOL的变化与FIQ结果的变化相关。
