Abstract:
In the present study, we have explored the involvement of Toll-like Receptor 4 (TLR4) in atrial fibrillation (AF), by using a meta-analysis of publicly available human transcriptomic data. The meta-analysis revealed 565 upregulated and 267 downregulated differentially expressed genes associated with AF. Pathway enrichment analysis highlighted a significant overrepresentation in immune-related pathways for the upregulated genes. A significant overlap between AF differentially expressed genes and TLR4-modulated genes was also identified, suggesting the potential role of TLR4 in AF-related transcriptional changes. Additionally, the analysis of other Toll-like receptors (TLRs) revealed a significant association with TLR2 and TLR3 in AF-related gene expression patterns. The examination of MYD88 and TICAM1, genes associated with TLR4 signalling pathways, indicated a significant yet nonspecific enrichment of AF differentially expressed genes. In summary, this study offers novel insights into the molecular aspects of AF, suggesting a pathophysiological role of TLR4 and other TLRs. By targeting these specific receptors, new treatments might be designed to better manage AF, offering hope for improved outcomes in affected patients.
摘要:
在本研究中,我们已经探讨了Toll样受体4(TLR4)在心房颤动(AF)中的参与,通过使用公开的人类转录组数据的荟萃分析。荟萃分析显示,与AF相关的差异表达基因有565个上调和267个下调。通路富集分析强调了上调基因在免疫相关通路中的显著过度表现。AF差异表达基因和TLR4调节基因之间的显著重叠也被鉴定。提示TLR4在AF相关转录变化中的潜在作用。此外,对其他Toll样受体(TLRs)的分析显示,在AF相关基因表达模式中,TLR2和TLR3显著相关。MYD88和TICAM1,与TLR4信号通路相关的基因的检查,表明AF差异表达基因的显着但非特异性富集。总之,这项研究为房颤的分子方面提供了新的见解,提示TLR4和其他TLRs的病理生理作用。通过靶向这些特定的受体,新的治疗方法可能是为了更好地管理房颤,为改善受影响患者的预后提供希望。