PDF(Pubmed)
Abstract：
In the present study, we have explored the involvement of Toll-like Receptor 4 (TLR4) in atrial fibrillation (AF), by using a meta-analysis of publicly available human transcriptomic data. The meta-analysis revealed 565 upregulated and 267 downregulated differentially expressed genes associated with AF. Pathway enrichment analysis highlighted a significant overrepresentation in immune-related pathways for the upregulated genes. A significant overlap between AF differentially expressed genes and TLR4-modulated genes was also identified, suggesting the potential role of TLR4 in AF-related transcriptional changes. Additionally, the analysis of other Toll-like receptors (TLRs) revealed a significant association with TLR2 and TLR3 in AF-related gene expression patterns. The examination of MYD88 and TICAM1, genes associated with TLR4 signalling pathways, indicated a significant yet nonspecific enrichment of AF differentially expressed genes. In summary, this study offers novel insights into the molecular aspects of AF, suggesting a pathophysiological role of TLR4 and other TLRs. By targeting these specific receptors, new treatments might be designed to better manage AF, offering hope for improved outcomes in affected patients.
摘要：
在本研究中,我们已经探讨了Toll样受体4（TLR4）在心房颤动（AF）中的参与，通过使用公开的人类转录组数据的荟萃分析。荟萃分析显示，与AF相关的差异表达基因有565个上调和267个下调。通路富集分析强调了上调基因在免疫相关通路中的显著过度表现。AF差异表达基因和TLR4调节基因之间的显著重叠也被鉴定。提示TLR4在AF相关转录变化中的潜在作用。此外,对其他Toll样受体（TLRs）的分析显示，在AF相关基因表达模式中，TLR2和TLR3显著相关。MYD88和TICAM1，与TLR4信号通路相关的基因的检查，表明AF差异表达基因的显着但非特异性富集。总之,这项研究为房颤的分子方面提供了新的见解，提示TLR4和其他TLRs的病理生理作用。通过靶向这些特定的受体，新的治疗方法可能是为了更好地管理房颤，为改善受影响患者的预后提供希望。
