PDF(Pubmed)
Abstract：
Cell-free nucleic acids (cf-NAs) represent a promising biomarker of various pathological and physiological conditions. Since its discovery in 1948, cf-NAs gained prognostic value in oncology, immunology, and other relevant fields. In peritoneal dialysis (PD), blood purification is performed by exposing the peritoneal membrane. Relevant sections: Complications of PD such as acute peritonitis and peritoneal membrane aging are often critical in PD patient management. In this review, we focused on bacterial DNA, cell-free DNA, mitochondrial DNA (mtDNA), microRNA (miRNA), and their potential uses as biomarkers for monitoring PD and its complications. For instance, the isolation of bacterial DNA in early acute peritonitis allows bacterial identification and subsequent therapy implementation. Cell-free DNA in peritoneal dialysis effluent (PDE) represents a marker of stress of the peritoneal membrane in both acute and chronic PD complications. Moreover, miRNA are promising hallmarks of peritoneal membrane remodeling and aging, even before its manifestation. In this scenario, with multiple cytokines involved, mtDNA could be considered equally meaningful to determine tissue inflammation.
This review explores the relevance of cf-NAs in PD, demonstrating its promising role for both diagnosis and treatment. Further studies are necessary to implement the use of cf-NAs in PD clinical practice.
This review explores the relevance of cf-NAs in PD, demonstrating its promising role for both diagnosis and treatment. Further studies are necessary to implement the use of cf-NAs in PD clinical practice.
摘要：
背景：无细胞核酸（cf-NA）代表了各种病理和生理状况的有希望的生物标志物。自1948年发现以来，cf-NAs在肿瘤学中获得了预后价值，免疫学,和其他相关领域。在腹膜透析（PD）中，通过暴露腹膜进行血液净化。相关章节：PD的并发症，如急性腹膜炎和腹膜老化通常是PD患者管理的关键。在这次审查中,我们专注于细菌DNA,无细胞DNA,线粒体DNA（mtDNA），microRNA(miRNA),以及它们作为监测PD及其并发症的生物标志物的潜在用途。例如,在早期急性腹膜炎中分离细菌DNA可以进行细菌鉴定和后续治疗.腹膜透析流出物（PDE）中的无细胞DNA代表急性和慢性PD并发症中腹膜压力的标志物。此外，miRNA是腹膜重塑和衰老的有希望的标志，甚至在它出现之前。在这种情况下，涉及多种细胞因子，mtDNA可以被认为对确定组织炎症同样有意义。
结论：这篇综述探讨了CF-NA在PD中的相关性，证明了它在诊断和治疗方面的有希望的作用。在PD临床实践中使用cf-NAs需要进一步的研究。
结论：这篇综述探讨了CF-NA在PD中的相关性，证明了它在诊断和治疗方面的有希望的作用。在PD临床实践中使用cf-NAs需要进一步的研究。
