Abstract：
Allergic rhinitis (AR), a common disease in otolaryngology, is a key risk factor for poorly controlled asthma and many complications, although it is not life-threatening. The negative impact of AR on social productive forces and human health is no less than that of asthma. Dendritic cells (DCs) play an important role in AR. In addition to sharing some of DC\'s biological characteristics, DCs-derived exosomes (DEXs) can promote the priming and activation of T cells and the maturation and differentiation of T helper type 2 (Th2) cells. Multiple signaling pathways in AR can be modulated by DEXs, which present allergens and participate in allergic immune responses. Anti-allergic drugs can be carried by DEXs to alleviate allergic airway inflammation and treat Th2-mediated AR effectively. Therefore, DEXs are crucial in the pathogenesis and treatment of AR.
摘要：
变应性鼻炎(AR),耳鼻咽喉科常见病,是哮喘控制不佳和许多并发症的关键危险因素，虽然没有生命危险.AR对社会生产力和人类健康的负面影响不亚于哮喘。树突状细胞(DCs)在AR中发挥重要作用。除了分享DC的一些生物学特征，DC来源的外泌体(DEXs)可以促进T细胞的启动和活化以及T辅助型2(Th2)细胞的成熟和分化。AR中的多个信号通路可以被DEXs调节，提供过敏原并参与过敏性免疫反应。DEXs携带抗过敏药物可缓解过敏性气道炎症，有效治疗Th2介导的AR。因此,DEXs在AR的发病机制和治疗中至关重要。
