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Abstract：
To evaluate the predictive and prognostic value of fibroblast growth factor 21 (FGF21) levels in retinal artery occlusion (RAO) patients. In this case-control study, serum FGF21 levels were detected by using the ELISA method. Multivariable logistic regression analyses were performed to evaluate the significance of FGF21 in assessing the risk of developing RAO and its impact on vision and concurrent ischemic stroke. Compared with control group, serum FGF21 levels were significantly higher (median [IQR] = 230.90[167.40,332.20] pg/ml) in RAO patients. Multivariate logistic regression analysis showed that elevated serum FGF21 levels were associated with a higher risk of RAO occurrence (P = 0.025, OR [95%CI] = 9.672 [2.573, 36.359]) after adjustment for multiple confounding factors. Higher serum FGF21 levels were negatively associated with visual acuity improvement (P = 0.029, OR [95%CI] = 0.466[0.235, 0.925]) and positively correlated with concurrent ischemic stroke (P = 0.04, OR [95% CI] = 1.944[1.029, 3.672]) in RAO patients. Elevated serum FGF21 levels could promote the development of RAO and indicate worse visual prognosis and increase the risk of concurrent ischemic stroke, which might help clinicians early diagnose and treat RAO patients.
摘要：
探讨成纤维细胞生长因子21(FGF21)水平对视网膜动脉阻塞(RAO)患者预后的预测价值。在这项病例对照研究中，采用ELISA法检测血清FGF21水平。进行了多变量逻辑回归分析，以评估FGF21在评估发生RAO的风险及其对视力和并发缺血性卒中的影响中的意义。与对照组相比,RAO患者血清FGF21水平显著升高(中位数[IQR]=230.90[167.40,332.20]pg/ml).多因素logistic回归分析显示，血清FGF21水平升高与RAO发生风险增加相关（P=0.025，OR[95CI]=9.672[2.573，36.359]）。RAO患者血清FGF21水平升高与视力改善呈负相关(P=0.029,OR[95CI]=0.466[0.235,0.925]),与并发缺血性卒中呈正相关(P=0.04,OR[95%CI]=1.944[1.029,3.672])。血清FGF21水平升高可促进RAO的发展，表明视力预后较差，并增加并发缺血性卒中的风险。这可能有助于临床医生早期诊断和治疗RAO患者。
