Abstract：
Fully absorbable meshes can repair abdominal wall defects and effectively reduce the incidence of complications, but different types of fully absorbable meshes have different remodeling and regeneration effects. In order to investigate and compare the effects of different fully absorbable meshes on remodeling and regeneration in animals and reduce the biological risk of clinical translation, SYRCLE was adopted to evaluate the methodological quality of the included studies, and GRADE and ConQual were used to evaluate the quality of evidence. According to the inclusion and exclusion criteria, a total of 22 studies related to fully absorbable meshes were included in this systematic review. These results showed that fiber-based synthetic materials and fiber-based natural materials exhibited better restorative and regenerative effects indicated by infiltration and neovascularization, when compared with a porcine acellular dermal matrix. In addition, the human acellular dermal matrix was found to have a similar regenerative effect on the host extracellular matrix and scaffold degradation compared to the porcine acellular dermal matrix, porcine intestinal submucosa, and fiber-based natural materials, but it offered higher tensile strength than the other three. The quality of the evidence in this field was found to be poor. The reasons for downgrading were analyzed, and recommendations for future research included more rigor in study design, more transparency in result reporting, more standardization of animal models and follow-up time for better evaluation of the remodeling and regenerative performance of abdominal wall hernia repair meshes, and less biological risk in clinical translation.
摘要：
完全可吸收网可以修复腹壁缺损，有效降低并发症的发生率。但不同类型的完全可吸收网有不同的重塑和再生效果。为了研究和比较不同完全可吸收网状物对动物重塑和再生的影响，降低临床转化的生物学风险，采用SYRCLE评估纳入研究的方法学质量，采用GRADE和ConQual对证据质量进行评价。根据纳入和排除标准，本系统综述共纳入了22项与完全可吸收网状物相关的研究.这些结果表明，纤维基合成材料和纤维基天然材料表现出更好的修复和再生效果，通过渗透和新生血管形成表明，与猪脱细胞真皮基质相比。此外,与猪脱细胞真皮基质相比，发现人脱细胞真皮基质对宿主细胞外基质和支架降解具有相似的再生作用，猪肠粘膜下层，和纤维基天然材料，但它提供了比其他三个更高的抗拉强度。该领域的证据质量较差。分析了降级的原因，对未来研究的建议包括更严格的研究设计，提高结果报告的透明度，更多的动物模型标准化和随访时间，以更好地评价腹壁疝修补术的重塑和再生性能，临床翻译中的生物学风险较小。
