METHODS: Medical records of 75 pediatric patients with GBS were reviewed for autonomic changes and GBS-associated PRES. Thirty-one developed dysautonomia while three were identified to have PRES. Clinical, radiological, laboratory, and treatment data were collected and analyzed.
RESULTS: All three patients were male and presented with symptoms of acute flaccid paralysis and respiratory distress requiring mechanical ventilation. All three patients experienced various complications, including hypertension, seizures, and hyponatremia, and were subsequently diagnosed with PRES. Multimodal intensive care resulted in patient improvement and discharge in an ambulatory state after an average of 104 days of care.
CONCLUSIONS: GBS-associated PRES is a rare and potentially life-threatening complication that can occur in pediatric patients with GBS. Our findings suggest that early recognition, prompt intervention, and multimodal intensive care can improve patient outcomes. Further studies are needed to determine optimal treatment strategies for GBS-associated PRES.
方法:回顾了75例GBS患儿的自主神经改变和GBS相关PRES的病历。31人患有自主神经失调,而3人被确定患有PRES。临床,放射学,实验室,收集和分析治疗数据。
结果:3例患者均为男性,表现为急性弛缓性麻痹和呼吸窘迫,需要机械通气。所有三名患者都经历了各种并发症,包括高血压,癫痫发作,低钠血症,随后被诊断为PRES。经过平均104天的护理,多模式重症监护使患者得到了改善,并在非卧床状态下出院。
结论:GBS相关PRES是一种罕见且可能危及生命的并发症,可发生在患有GBS的儿科患者中。我们的研究结果表明,早期认识,及时干预,多模式重症监护可以改善患者预后。需要进一步的研究来确定GBS相关PRES的最佳治疗策略。