Abstract：
Bone graft materials are often used in implant treatment to optimize functional and esthetic outcomes. The requirements for bone grafting materials are the ability to maintain space for bone regeneration to occur and the capability of being resorbed by osteoclasts and replaced with new bone tissue occurring in passive chemolysis and bone remodeling. Carbonate apatite (CO3Ap) granules (Cytrans Granules, GC) are a chemically synthetic bone graft material similar to autogenous bone minerals and more biocompatible than allografts and xenografts. The aim of this report is to evaluate the efficacy of CO3Ap granules in implant treatments when used alone or in combination with autogenous bone. The clinical findings and the radiographic and histologic assessments in three cases of immediate implant placement and lateral and vertical guided bone regeneration are reported. Despite the short-term follow-ups, histologic findings showed that CO3Ap granules were efficiently resorbed and replaced bone in clinical use. Furthermore, the clinical findings showed that CO3Ap granules maintained their morphology around the implant. This limited short-term case report suggests that this bone substitute is effective. However, further clinical studies and long-term reports of this new biomaterial are needed.
摘要：
骨移植材料通常用于植入物治疗以优化功能和美学结果。对骨移植材料的要求是保持发生骨再生的空间的能力以及被破骨细胞吸收并被被动化学分解和骨重建中发生的新骨组织取代的能力。碳酸盐磷灰石（CO3Ap）颗粒（Cytrans颗粒，GC）是一种化学合成的骨移植材料，类似于自体骨矿物质，比同种异体移植物和异种移植物更具生物相容性。本报告的目的是评估CO3Ap颗粒单独或与自体骨联合使用时在植入物治疗中的功效。报告了三例立即放置植入物以及横向和垂直引导骨再生的临床发现以及影像学和组织学评估。尽管有短期的后续行动,组织学发现表明，CO3Ap颗粒在临床使用中可有效吸收和替代骨骼。此外，临床发现表明，CO3Ap颗粒在植入物周围保持形态。这个有限的短期病例报告表明这种骨替代物是有效的。然而,这种新的生物材料需要进一步的临床研究和长期报告.
