PDF(Pubmed)
Abstract：
Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study assessed the effect of post-conization HPV vaccination on the viral status of women at six months post-conization, aiming to evaluate the vaccine\'s effectiveness in preventing recurrence of CIN2+. A retrospective cohort study was conducted among women in Troms and Finnmark who underwent conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK), we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met the inclusion criteria. A significant association was found between post-conization HPV vaccination and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its potential in preventing the recurrence of high-grade cellular changes. However, the retrospective design and the insufficient control of confounding variables in this study underscore the need for further studies to confirm these findings.
摘要：
人乳头瘤病毒（HPV）与导致癌症的子宫颈细胞变化有关，这突出了疫苗接种在预防HPV感染和随后的细胞变化中的重要性。接受环形电切术（LEEP）的女性，高级别宫颈上皮内瘤变（CIN2+）的治疗，仍有复发的风险。这项研究评估了锥化后HPV疫苗接种对锥化后六个月女性病毒状况的影响，旨在评估疫苗预防CIN2+复发的有效性。在2022年接受锥切术的Troms和Finnmark妇女中进行了一项回顾性队列研究。使用SymPathy数据库和国家疫苗接种登记册（SYSVAK），我们分析了1991年之前出生的女性的疫苗接种情况和HPV检测结果,这些女性在锥切前未接种HPV疫苗.在419名接受锥切术的妇女中，243符合纳入标准。在六个月的随访中，锥化后HPV疫苗接种与HPV检测阴性之间存在显着关联（ARR=12.1％，p=0.039)。锥切后HPV疫苗接种显着降低了第一次随访时HPV检测阳性的风险，提示其在预防高级别细胞变化复发方面的潜力。然而,本研究的回顾性设计和对混杂变量的控制不足,强调了需要进一步的研究来证实这些发现.
