PDF(Pubmed)
Abstract：
Probiotics, including Streptococcus dentisani, have been proposed as an alternative to re-establish the ecology of the oral cavity and inhibit the formation of pathogenic biofilms. The main objective of this work was to assess the probiotic ability of S. dentisani against Streptococcus mutans, Streptococcus mitis, and Candida albicans biofilms. The ability of the strains to form a monospecies biofilm and the probiotic potential of S. dentisani using the competition, exclusion, and displacement strategies were determined. All strains were moderate biofilm producers. The ability of S. dentisani to compete with and exclude S. mutans and S. mitis during biofilm formation was not significant. However, S. dentisani significantly reduced pathologic streptococcal biofilms using the displacement strategy. Also S. dentisani reduced the formation of the C. albicans biofilm mainly through competition and displacement. In vitro, S. dentisani exhibited probiotic potential to reduce the formation of potentially pathogenic biofilms. Further investigation is required to understand the biofilm-inhibiting mechanisms exhibited by this probiotic strain.
摘要：
益生菌,包括牙本质链球菌,已被提出作为重建口腔生态和抑制致病性生物膜形成的替代方案。这项工作的主要目的是评估牙菌病对变形链球菌的益生菌能力，米炎链球菌，和白色念珠菌生物膜。菌株形成单种生物膜的能力和使用竞争的牙本质链球菌的益生菌潜力，排除,并确定了流离失所策略。所有菌株均为中度生物膜生产者。牙本质链球菌在生物膜形成过程中与变形链球菌和S.mitis竞争和排除的能力并不显著。然而,牙本质链球菌使用置换策略显著减少病理性链球菌生物膜。牙本质链球菌主要通过竞争和置换减少白色念珠菌生物膜的形成。体外，牙本质杆菌表现出益生菌潜力，可减少潜在致病性生物膜的形成。需要进一步的研究来了解这种益生菌菌株表现出的生物膜抑制机制。
