PDF(Pubmed)
Abstract：
Niosomes are arousing significant interest thanks to their low cost, high biocompatibility, and negligible toxicity. In this work, a supercritical CO2-assisted process was performed at 100 bar and 40 °C to produce niosomes at different Span 80/Tween 80 weight ratios. The formulation of cholesterol and 80:20 Span 80/Tween 80 was selected to encapsulate vancomycin, used as a model active compound, to perform a drug release rate comparison between PEGylated and non-PEGylated niosomes. In both cases, nanometric vesicles were obtained, i.e., 214 ± 59 nm and 254 ± 73 nm for non-PEGylated and PEGylated niosomes, respectively, that were characterized by a high drug encapsulation efficiency (95% for non-PEGylated and 98% for PEGylated niosomes). However, only PEGylated niosomes were able to prolong the vancomycin release time up to 20-fold with respect to untreated drug powder, resulting in a powerful strategy to control the drug release rate.
摘要：
Niosomes由于其低成本而引起了极大的兴趣，高生物相容性，和微不足道的毒性。在这项工作中,在100巴和40°C下进行超临界CO2辅助工艺以产生不同Span80/Tween80重量比的囊泡。选择胆固醇和80：20Span80/Tween80的配方来封装万古霉素，用作模型活性化合物，进行聚乙二醇化和非聚乙二醇化囊泡之间的药物释放率比较。在这两种情况下，获得了纳米囊泡，即，214±59nm和254±73nm的非聚乙二醇化和聚乙二醇化的脂质体，分别,其特征在于高的药物包封效率(非聚乙二醇化为95%,聚乙二醇化为98%)。然而,只有聚乙二醇化的脂质体能够将万古霉素释放时间延长至未经处理的药物粉末的20倍，从而产生控制药物释放速率的强大策略。
