PDF(Pubmed)
Abstract：
Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study, seven previously reported compounds were isolated including auraptene, 6\'-dehydromarmin, geiparvarin, marmin acetonide, flindersine, and two flindersine derivatives from the bark and leaves, together with a new compound, chlorogeiparvarin, formed as an artefact during the isolation procedure and isolated as a mixture with geiparvarin. Chemical profiling allowed for a qualitative and quantitative comparison of the compounds in the leaves, bark, flowers, and fruit of this plant. Subsequently, a subset of these compounds as well as crude extracts from the plant were evaluated for their antimicrobial and anthelmintic activities. Anthelmintic activity assays showed that two of the isolated compounds, auraptene and flindersine, as well as the dichloromethane and methanol crude extracts of G. parviflora, displayed significant activity against a parasitic nematode (Haemonchus contortus). This is the first report of the anthelmintic activity associated with these compounds and indicates the importance of such fundamental explorations for the discovery of bioactive phytochemicals for therapeutic application(s).
摘要：
植物化学分析，然后对澳大利亚植物Geijeraparviflora进行抗菌和驱虫活性评估，以其在澳大利亚土著仪式和布什医学中的惯用而闻名，已执行。在本研究中,分离出七个先前报道的化合物，包括月桂烯，6\'-dhydromymin,Geiparvarin,马明丙酮,Flindersine,和两个来自树皮和叶子的氟inderine衍生物，连同一种新的化合物，氯龙舌兰,在分离过程中形成为人工制品，并与geiparvarin混合分离。化学分析可以对叶子中的化合物进行定性和定量比较，吠叫,鲜花,和这种植物的果实。随后，评估了这些化合物的一部分以及植物的粗提物的抗菌和驱虫活性。驱虫活性测定表明，两种分离的化合物，Auraptene和Flindersine，以及parviflora的二氯甲烷和甲醇粗提物，对寄生线虫（Haemonchuscontortus）表现出明显的活性。这是与这些化合物相关的驱虫活性的首次报道,并表明了这些基本探索对于发现用于治疗性应用的生物活性植物化学物质的重要性。
