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Abstract：
Blood count is crucial for assessing bone marrow\'s cell production and differentiation during infections, gaging disease severity, and monitoring therapeutic responses. The profile of blood count in chronic forms of paracoccidioidomycosis (PCM) has been insufficiently explored. To better understand the changes in hematological cells in different stages of the PCM chronic form, we evaluated the blood count, including immature blood cells in automated equipment, before and during the treatment follow-up of 62 chronic PCM patients. Predominantly male (96.8%) with an average age of 54.3 (standard deviation SD 6.9) years, participants exhibited pre-treatment conditions such as anemia (45.2%), monocytosis (38.7%), and leukocytosis (17.7%), which became less frequent after clinical cure. Anemia was more prevalent in severe cases. Notably, hemoglobin and reticulocyte hemoglobin content increased, while leukocytes, monocytes, neutrophils, immature granulocytes, and platelets decreased. Chronic PCM induced manageable hematological abnormalities, mainly in the red blood series. Monocytosis, indicating monocytes\' role in PCM\'s immune response, was frequent. Post-treatment, especially after achieving clinical cure, significant improvements were observed in various hematological indices, including immature granulocytes and reticulocyte hemoglobin content, underscoring the impact of infection on these parameters.
摘要：
血细胞计数对于评估感染期间骨髓细胞的产生和分化至关重要，测量疾病的严重程度，并监测治疗反应。慢性形式的副角菌病（PCM）的血细胞计数特征尚未得到充分探索。为了更好地了解PCM慢性形式的不同阶段的血液细胞的变化，我们评估了血细胞计数,包括自动化设备中未成熟的血细胞，对62例慢性PCM患者进行治疗前和治疗期间的随访。主要为男性（96.8%），平均年龄为54.3（标准差为6.9）岁，参与者表现出治疗前的状况，如贫血(45.2%)，单核细胞增多症（38.7%），和白细胞增多（17.7％），临床治愈后变得不那么频繁。贫血在严重病例中更为普遍。值得注意的是,血红蛋白和网织红细胞血红蛋白含量增加，而白细胞，单核细胞,中性粒细胞，未成熟粒细胞，血小板减少。慢性PCM引起可管理的血液学异常，主要是红血丝系列。单核细胞增多症,指示单核细胞在PCM的免疫反应中的作用，是频繁的。后处理,尤其是在达到临床治愈后，在各种血液学指标中观察到显着改善，包括未成熟粒细胞和网织红细胞血红蛋白含量，强调感染对这些参数的影响。
