PDF(Pubmed)
Abstract：
Despite reductions in bacterial infection and enhanced success rate, the widespread use of systemic antibiotic prophylaxis in implant dentistry is controversial. This use has contributed to the growing problem of antimicrobial resistance, along with creating significant health and economic burdens. The basic mechanisms that cause implant infection can be targeted by new prevention and treatment methods which can also lead to the reduction of systemic antibiotic exposure and its associated adverse effects. This review aims to summarize advanced biomaterial strategies applied to implant components based on anti-pathogenic mechanisms and immune balance mechanisms. It emphasizes that modifying the dental implant surface and regulating the early immune response are promising strategies, which may further prevent or slow the development of peri-implant infection, and subsequent failure.
摘要：
尽管细菌感染减少，成功率提高，在种植牙科中广泛使用全身性抗生素预防是有争议的.这种使用导致了日益增长的抗菌素耐药性问题，同时造成巨大的健康和经济负担。引起植入物感染的基本机制可以通过新的预防和治疗方法来靶向,这也可以导致全身性抗生素暴露及其相关副作用的减少。本文旨在总结基于抗致病机制和免疫平衡机制的先进生物材料应用于植入物组件的策略。它强调修饰牙种植体表面和调节早期免疫反应是有前途的策略，这可以进一步预防或减缓植入物周围感染的发展，随后的失败。
