PDF(Pubmed)
Abstract：
Skin is the primary and largest protective organ of the human body. It produces a number of highly evolved arsenal of factors to counter the continuous assault of foreign materials and pathogens from the environment. One such potent factor is the repertoire of Antimicrobial Peptides (AMPs) that not only directly destroys invading pathogens, but also optimally modulate the immune functions of the body to counter the establishment and spread of infections. The canonical direct antimicrobial functions of these AMPs have been in focus for a long time to design principles for enhanced therapeutics, especially against the multi-drug resistant pathogens. However, in recent times the immunomodulatory functions performed by these peptides at sub-microbicidal concentrations have been a point of major focus in the field of host-directed therapeutics. Such strategies have the added benefit of not having the pathogens develop resistance against the immunomodulatory pathways, since the pathogens exploit these signaling pathways to obtain and survive within the host. Thus, this review summarizes the potent immunomodulatory effect of these AMPs on, specifically, the different host immune cells with the view of providing a platform of information that might help in designing studies to exploit and formulate effective host-directed adjunct therapeutic strategies that would synergies with drug regimens to counter the current diversity of drug-resistant skin opportunistic pathogens.
摘要：
皮肤是人体的主要和最大的保护器官。它产生了许多高度进化的因素，以应对来自环境的外来物质和病原体的持续攻击。一个这样的有效因素是抗菌肽（AMP）的库，不仅直接破坏入侵的病原体，而且还可以最佳地调节身体的免疫功能，以抵抗感染的建立和传播。这些AMP的典型直接抗微生物功能长期以来一直是人们关注的焦点，以设计增强疗法的原理。特别是针对多药耐药的病原体。然而,近来,这些肽在亚杀微生物浓度下执行的免疫调节功能已成为宿主定向治疗领域的主要焦点。这样的策略具有不使病原体产生针对免疫调节途径的抗性的额外益处。因为病原体利用这些信号通路来获得并在宿主内存活。因此，这篇综述总结了这些AMPs对，具体来说,不同宿主免疫细胞的目的是提供一个信息平台，这可能有助于设计研究，以利用和制定有效的宿主为导向的辅助治疗策略，这些策略将与药物方案协同作用，以对抗当前耐药性皮肤机会病原体的多样性。
