PDF(Pubmed)
Abstract：
Scorpion venom peptides are generally classified into two main groups: the disulfide bridged peptides (DBPs), which usually target membrane-associated ion channels, and the non-disulfide bridged peptides (NDBPs), a smaller group with multifunctional properties. In the past decade, these peptides have gained interest because most of them display functions that include antimicrobial, anticancer, haemolytic, and anti-inflammatory activities. Our current study focuses on the short (9-19 amino acids) antimicrobial linear scorpion peptides. Most of these peptides display a net positive charge of 1 or 2, an isoelectric point at pH 9-10, a broad range of hydrophobicity, and a Grand Average of Hydropathy (GRAVY) Value ranging between -0.05 and 1.7. These features allow these peptides to be attracted toward the negatively charged phospholipid head groups of the lipid membranes of target cells, a force driven by electrostatic interactions. This review outlines the antimicrobial potential of short-chained linear scorpion venom peptides. Additionally, short linear scorpion peptides are in general more attractive for large-scale synthesis from a manufacturing point of view. The structural and functional diversity of these peptides represents a good starting point for the development of new peptide-based therapeutics.
摘要：
蝎毒肽通常分为两大类：二硫键桥接肽（DBPs），通常靶向膜相关离子通道，和非二硫键桥接肽（NDBPs），具有多功能属性的较小的组。在过去的十年里,这些肽已经获得了兴趣，因为它们中的大多数显示功能，包括抗微生物，抗癌，溶血性,和抗炎活性。我们目前的研究集中在短（9-19个氨基酸）抗微生物线性蝎肽上。这些肽中的大多数显示1或2的净正电荷，在pH9-10的等电点，广泛的疏水性，以及在-0.05和1.7之间范围内的平均积水(GRAVY)值。这些特征允许这些肽被吸引到靶细胞的脂质膜的带负电荷的磷脂头部基团。由静电相互作用驱动的力。这篇综述概述了短链线性蝎毒肽的抗菌潜力。此外,从制造角度来看，短线性蝎子肽通常对于大规模合成更具吸引力。这些肽的结构和功能多样性代表了开发新的基于肽的治疗剂的良好起点。
