PDF(Pubmed)
Abstract：
Cellular demise is a pivotal event in both developmental processes and disease states, with mitochondrial regulation playing an essential role. Traditionally, cell death was categorized into distinct types, considered to be linear and mutually exclusive pathways. However, the current understanding has evolved to recognize the complex and interconnected mechanisms of cell death, especially within apoptosis, pyroptosis, and necroptosis. Apoptosis, pyroptosis, and necroptosis are governed by intricate molecular pathways, with mitochondria acting as central decision-makers in steering cells towards either apoptosis or pyroptosis through various mediators. The choice between apoptosis and necroptosis is often determined by mitochondrial signaling and is orchestrated by specific proteins. The molecular dialogue and the regulatory influence of mitochondria within these cell death pathways are critical research areas. Comprehending the shared elements and the interplay between these death modalities is crucial for unraveling the complexities of cellular demise.
摘要：
细胞死亡是发育过程和疾病状态中的关键事件，线粒体调节起着至关重要的作用。传统上,细胞死亡被分为不同的类型，被认为是线性和互斥的途径。然而,目前的理解已经发展到认识到细胞死亡的复杂和相互关联的机制，特别是在细胞凋亡中，焦亡,和坏死。细胞凋亡,焦亡,坏死是由复杂的分子途径控制的，线粒体是通过各种介体引导细胞走向凋亡或焦亡的主要决策者。凋亡和坏死之间的选择通常由线粒体信号决定，并由特定的蛋白质协调。分子对话和线粒体在这些细胞死亡途径中的调节影响是关键的研究领域。理解共享元素和这些死亡方式之间的相互作用对于解开细胞死亡的复杂性至关重要。
